阳离子卟啉诱导端粒 DNA 在水中形成 G-四链体。
Cationic porphyrin induced a telomeric DNA to g-quadruplex form in water.
机构信息
Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan.
出版信息
Bioinorg Chem Appl. 2008;2008:294756. doi: 10.1155/2008/294756.
Abstract
The formation of the DNA G-quadruplex is induced by the addition of a novel porphyrin carrying four cationic tethers. Circular dichroism spectroscopy reveals that the porphyrin binds to Tetrahymena telomeric repeat to form G-quadruplex under stabilizing-cation-deficient and no buffer conditions.
摘要
新型卟啉携带四个正电荷连接臂，通过添加该卟啉诱导 DNA G-四链体的形成。圆二色光谱表明，在稳定化阳离子缺乏和无缓冲条件下，该卟啉与四膜虫端粒重复序列结合形成 G-四链体。
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