Ashcroft G P, Entwisle S J, Campbell C J, Holden M P, Keene O N
Department of Cardiothoracic Surgery, Freeman Road Hospital, Newcastle upon Tyne.
Thorac Cardiovasc Surg. 1991 Aug;39(4):183-6. doi: 10.1055/s-2007-1013959.
Immunoreactive atrial natriuretic factor (ANF) levels were measured in blood taken from superior vena cava, right atrium, pulmonary artery, pulmonary vein, left atrium, and radial arteries in patients undergoing cardiac surgery. Significant (p less than 0.05) differences were seen between sites. Levels of atrial natriuretic factor were seen to rise from superior vena cava (27.5 pmol/L) to right atrium (54.3 pmol/L) and then fall in pulmonary artery (38.5 pmol/L). A further significant fall was seen in pulmonary vein (32.7 pmol/L) samples. There was no significant change in levels in left atrium (32.1 pmol/L) or radial artery (30 pmol/L). The fall between radial artery levels and superior vena caval levels was also significant. The rise from superior vena cava to right atrium is to be expected as this represents the major site of addition of atrial natriuretic factor to the circulation. We propose that the fall in levels from right atrium to pulmonary artery and from pulmonary artery to pulmonary vein suggests uptake and therefore possible local hormonal action on both right ventricle and pulmonary vasculature. The fall from radial artery to vena cava would be in keeping with atrial natriuretic factor's known systemic uptake and action.
在接受心脏手术的患者中，测量了取自上腔静脉、右心房、肺动脉、肺静脉、左心房和桡动脉的血液中的免疫反应性心房利钠因子（ANF）水平。各部位之间存在显著（p<0.05）差异。心房利钠因子水平从上腔静脉（27.5 pmol/L）升至右心房（54.3 pmol/L），然后在肺动脉（38.5 pmol/L）下降。肺静脉（32.7 pmol/L）样本中出现进一步显著下降。左心房（32.1 pmol/L）或桡动脉（30 pmol/L）水平无显著变化。桡动脉水平与上腔静脉水平之间的下降也很显著。从上腔静脉到右心房的升高是可以预期的，因为这代表了心房利钠因子进入循环的主要部位。我们认为，从右心房到肺动脉以及从肺动脉到肺静脉的水平下降表明存在摄取，因此可能对右心室和肺血管系统有局部激素作用。从桡动脉到腔静脉的下降与心房利钠因子已知的全身摄取和作用一致。
