Singer D R, Dean J W, Buckley M G, Sagnella G A, MacGregor G A
Br Heart J. 1987 Jul;58(1):24-8. doi: 10.1136/hrt.58.1.24.
Plasma concentrations of atrial natriuretic peptide were measured in eight patients undergoing elective cardiac catheterisation and angiography. All patients had normal resting pressures in the cardiac chambers and no clinical evidence of heart failure. Plasma atrial natriuretic peptide rose significantly from the superior vena cava into the right atrium and right ventricle. The increase into the right atrium was variable, with no increase in three subjects, but there was a consistent increase in all subjects from the superior vena cava to to the right ventricle. These findings in the right atrium are probably caused by inadequate mixing and streaming of blood from the coronary sinus containing high concentrations of atrial natriuretic peptide. There was no increase in the concentration of natriuretic peptide from the pulmonary artery to the left ventricle, but the concentrations in the left ventricle were significantly higher than in the superior vena cava. These findings demonstrate that the heart secretes atrial natriuretic peptides in the absence of cardiac failure. Studies based on sampling of the right atrium will not accurately measure cardiac secretion of atrial natriuretic peptide and will therefore be likely to obscure the mechanisms responsible for regulating its secretion. The right ventricle and pulmonary artery are the best sampling sites to measure atrial natriuretic peptide release from the right atrium.
对8例接受择期心导管插入术和血管造影术的患者测定了血浆心房利钠肽浓度。所有患者心腔静息压力均正常，且无心力衰竭的临床证据。血浆心房利钠肽从 Superior vena cava（上腔静脉）到右心房和右心室显著升高。进入右心房的升高情况不一，3名受试者无升高，但所有受试者从上腔静脉到右心室均持续升高。右心房的这些发现可能是由于来自含有高浓度心房利钠肽的冠状窦的血液混合和流动不充分所致。从肺动脉到左心室，利钠肽浓度没有升高，但左心室的浓度明显高于上腔静脉。这些发现表明，在无心力衰竭的情况下，心脏会分泌心房利钠肽。基于右心房采样的研究无法准确测量心房利钠肽的心脏分泌，因此可能会掩盖调节其分泌的机制。右心室和肺动脉是测量右心房释放心房利钠肽的最佳采样部位。
