可生物降解聚原酸酯与脱矿骨基质复合材料在大鼠体内的骨诱导作用
Bone induction by composite of bioerodible polyorthoester and demineralized bone matrix in rats.
作者信息
Pinholt E M, Solheim E, Bang G, Sudmann E
机构信息
Institute for Surgical Research, Rikshospitalet, University of Oslo, Norway.
出版信息
Acta Orthop Scand. 1991 Oct;62(5):476-80. doi: 10.3109/17453679108996649.
PMID:1835243
Abstract
A composite of a local, sustained, drug-release system, Alzamer bioerodible polyorthoester, and demineralized bone-matrix (DBM) particles implanted in the abdominal muscle of 89 Wistar rats induced cartilage and bone formation at the same rate as DBM when evaluated histologically and by 85Sr uptake. The composite implant was technically easier to use than DBM alone.
摘要
一种由局部、持续药物释放系统（阿尔扎默生物可蚀解聚原酸酯）和脱矿骨基质（DBM）颗粒组成的复合物，植入89只Wistar大鼠的腹部肌肉中，通过组织学评估和85Sr摄取发现，其诱导软骨和骨形成的速率与DBM相同。该复合植入物在技术上比单独使用DBM更易于操作。
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