脱矿异体骨基质在骨骼外部位的实验性骨生成

Experimental osteogenesis with demineralized allogeneic bone matrix in extraskeletal sites.

作者信息

Narang R, Wells H, Laskin D M

出版信息

J Oral Maxillofac Surg. 1982 Mar;40(3):133-41. doi: 10.1016/0278-2391(82)90044-1.

Abstract

Male albino rats were used to study the osteogenic potential of demineralized allogeneic bone matrix (DABM) grafts, in different stages of demineralization, placed in the anterior abdominal wall. The clinical evaluation, radiologic examination, calcium determination, and histologic (light and electron microscopic) studies showed that completely demineralized allogeneic bone matrix (CDABM) grafts were not rejected and that they stimulated new bone formation at the transplant sites. On the other hand, partially demineralized allogeneic bone matrix (PDABM) grafts were frequently rejected and showed minimal bone induction and gradual demineralization.

摘要

雄性白化大鼠被用于研究置于前腹壁的不同脱矿阶段的同种异体脱矿骨基质（DABM）移植物的成骨潜力。临床评估、放射学检查、钙测定以及组织学（光镜和电镜）研究表明，完全脱矿的同种异体骨基质（CDABM）移植物未被排斥，并且它们在移植部位刺激了新骨形成。另一方面，部分脱矿的同种异体骨基质（PDABM）移植物经常被排斥，并且显示出最小的骨诱导和逐渐脱矿。