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兔节段性骨缺损模型中不同骨移植基质的可比骨愈合能力

Comparable bone healing capacity of different bone graft matrices in a rabbit segmental defect model.

作者信息

Kim Jong Min, Kim Myoung Hwan, Kang Seong Soo, Kim Gonhyung, Choi Seok Hwa

机构信息

Xenotransplantation Research Center, Biomedical Research Institute, Seoul National University Hospital, Seoul 153-832, Korea.

出版信息

J Vet Sci. 2014;15(2):289-95. doi: 10.4142/jvs.2014.15.2.289. Epub 2014 Mar 21.

DOI:10.4142/jvs.2014.15.2.289
PMID:24675830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4087232/
Abstract

We compared the bone healing capacity of three different demineralized bone matrix (DBM) products applied using different carrier molecules (hyaluronic acid [HA] vs. carboxymethylcellulose [CMC]) or bone compositions (cortical bone vs. cortical bone and cancellous bone) in a rabbit segmental defect model. Overall, 15-mm segmental defects in the left and right radiuses were created in 36 New Zealand White rabbits and filled with HA-based demineralized cortical bone matrix (DBX), CMC-based demineralized cortical bone matrix (DB) or CMC-based demineralized cortical bone with cancellous bone (NDDB), and the wound area was evaluated at 4, 8, and 12 weeks post-implantation. DBX showed significantly lower radiopacity, bone volume fraction, and bone mineral density than DB and NDDB before implantation. However, bone healing score, bone volume fraction, bone mineral density, and residual bone area at 4, 8, and 12 weeks post-implantation revealed no significant differences in bone healing capacity. Overall, three DBM products with different carrier molecules or bone compositions showed similar bone healing capacity.

摘要

我们在兔节段性缺损模型中，比较了使用不同载体分子（透明质酸[HA]与羧甲基纤维素[CMC]）或骨成分（皮质骨与皮质骨加松质骨）应用的三种不同脱矿骨基质（DBM）产品的骨愈合能力。总体而言，在36只新西兰白兔的左右桡骨上制造了15毫米的节段性缺损，并用基于HA的脱矿皮质骨基质（DBX）、基于CMC的脱矿皮质骨基质（DB）或基于CMC的含松质骨的脱矿皮质骨（NDDB）填充，并在植入后4周、8周和12周评估伤口面积。植入前，DBX的射线不透性、骨体积分数和骨矿物质密度显著低于DB和NDDB。然而，植入后4周、8周和12周时的骨愈合评分、骨体积分数、骨矿物质密度和残余骨面积显示，骨愈合能力没有显著差异。总体而言，三种具有不同载体分子或骨成分的DBM产品显示出相似的骨愈合能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/489a/4087232/9e6f9be1b416/jvs-15-289-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/489a/4087232/655be0d51d26/jvs-15-289-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/489a/4087232/f2c2bcdab2fa/jvs-15-289-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/489a/4087232/2eed42c62de9/jvs-15-289-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/489a/4087232/0b220bf3b647/jvs-15-289-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/489a/4087232/ef0abb80ea3d/jvs-15-289-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/489a/4087232/994e25654e1c/jvs-15-289-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/489a/4087232/9e6f9be1b416/jvs-15-289-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/489a/4087232/655be0d51d26/jvs-15-289-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/489a/4087232/f2c2bcdab2fa/jvs-15-289-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/489a/4087232/2eed42c62de9/jvs-15-289-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/489a/4087232/0b220bf3b647/jvs-15-289-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/489a/4087232/ef0abb80ea3d/jvs-15-289-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/489a/4087232/994e25654e1c/jvs-15-289-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/489a/4087232/9e6f9be1b416/jvs-15-289-g007.jpg

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