Dayanir Volkan, Cakmak Harun, Berkit Ilker
Department of Ophthalmology, School of Medicine, Adnan Menderes University, Aydin, Turkey.
Clin Exp Ophthalmol. 2008 Mar;36(2):136-41. doi: 10.1111/j.1442-9071.2008.01698.x.
To determine if the intraocular pressure (IOP) reduction in one-eye trial correlates with the IOP reduction in the fellow eye when IOP variability during office hours is taken into account.
This retrospective observational case series includes 50 high tension (primary open-angle glaucoma, exfoliative glaucoma and ocular hypertension; Group 1) and 21 normal tension (Group 2) glaucoma patients. Charts of bilateral open-angle glaucoma patients at Glaucoma Unit, School of Medicine, Adnan Menderes University who had pretreatment baseline office IOP measurements at 9:30, 11:30 and 15:30; were put on a one-eye trial with prostaglandin analogues, and then subsequently received the same medication in the fellow eye were reviewed. Pretreatment baseline office IOP measurements and reductions in the first and second eyes were compared to determine variability and correlation, respectively.
Both groups showed significant variability in pretreatment baseline office IOP measurements. Peak IOP level was before noon in at least 70% of eyes in Group 1, 50% in Group 2. IOP dropped a mean of 8.8 +/- 4.8 mmHg (34%, P = < 0.0001) in Group 1 and 4.9 +/- 2.4 mmHg (30%, P = < 0.0001) in Group 2 during the one-eye trial. Following bilateral use of the medication a mean drop of 7.5 +/- 4.0 mmHg (31%, P = < 0.0001) in Group 1 and 2.9 +/- 1.9 mmHg (18%, P = < 0.0001) in Group 2 were obtained. The IOP reduction between fellow-eye pairs were significantly correlated in Group 1 (r = 0.541, P = < 0.0001) but not Group 2 (r =-0.310, P = 0.171).
One-eye trial is a feasible method to determine the effectiveness of prostaglandin analogues and to predict the amount of IOP reduction in the fellow eye in patients with high tension glaucoma.
在考虑办公时间眼压变异性的情况下，确定单眼试验中眼压降低与对侧眼眼压降低之间是否相关。
这项回顾性观察性病例系列研究纳入了50例高眼压患者（原发性开角型青光眼、剥脱性青光眼和高眼压症；第1组）和21例正常眼压青光眼患者（第2组）。回顾了阿德南·门德雷斯大学医学院青光眼科双侧开角型青光眼患者的病历，这些患者在9:30、11:30和15:30进行了治疗前基线办公眼压测量；对一只眼睛使用前列腺素类似物进行单眼试验，随后对另一只眼睛使用相同药物。比较治疗前基线办公眼压测量值以及第一眼和第二眼的眼压降低情况，分别以确定变异性和相关性。
两组患者治疗前基线办公眼压测量值均显示出显著变异性。第1组至少70%的眼睛眼压峰值出现在中午之前，第2组为50%。在单眼试验期间，第1组眼压平均下降8.8±4.8 mmHg（34%，P = < 0.0001），第2组眼压平均下降4.9±2.4 mmHg（30%，P = < 0.0001）。双眼使用药物后，第1组眼压平均下降7.5±4.0 mmHg（31%，P = < 0.0001），第2组眼压平均下降2.9±1.9 mmHg（18%，P = < 0.0001）。第1组对侧眼之间的眼压降低显著相关（r = 0.541，P = < 0.0001），但第2组不相关（r = -0.310，P = 0.171）。
单眼试验是确定前列腺素类似物有效性以及预测高眼压青光眼患者对侧眼眼压降低幅度的一种可行方法。
