Atsma Femke, Bartelink Marie-Louise E L, van der Schouw Yvonne T, Kors Jan A, Grobbee Diederick E
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
J Electrocardiol. 2008 Jul-Aug;41(4):360-4. doi: 10.1016/j.jelectrocard.2008.01.001. Epub 2008 Mar 19.
Frontal T axis and spatial QRS-T angle are both measures of disturbances in ventricular repolarization and depolarization. We determined whether increased blood pressure is a risk factor for changes in these parameters in postmenopausal women free of left ventricular hypertrophy.
This cross-sectional study included 969 women. A standard 12-lead electrocardiogram (ECG) was recorded, and frontal T axes and spatial QRS-T angles were computed from vectorcardiography. Logistic regression analysis was used to assess the relationship between systolic and diastolic blood pressures on the one hand and both ECG parameters on the other.
Odds ratios were 1.08 (95% confidence interval [CI], 0.99-1.18) and 1.12 (95% CI, 1.03-1.23) per 10 mm Hg systolic blood pressure for frontal T axis and QRS-T angle, respectively. These values were 1.05 (95% CI, 0.95-1.16) and 1.12 (95% CI, 1.02-1.23) per 5 mm Hg diastolic blood pressure for frontal T-axis and QRS-T angle, respectively.
Elevated blood pressure may lead to ventricular depolarization and repolarization disturbances before overt ECG left ventricular hypertrophy has developed.
额面T轴和空间QRS-T角均为心室复极化和去极化紊乱的测量指标。我们确定血压升高是否是无左心室肥厚的绝经后女性这些参数变化的危险因素。
这项横断面研究纳入了969名女性。记录标准12导联心电图（ECG），并从心电向量图计算额面T轴和空间QRS-T角。采用逻辑回归分析评估收缩压和舒张压一方面与两个心电图参数另一方面之间的关系。
收缩压每升高10 mmHg，额面T轴和QRS-T角的比值比分别为1.08（95%置信区间[CI]，0.99 - 1.18）和1.12（95%CI，1.03 - 1.23）。舒张压每升高5 mmHg，额面T轴和QRS-T角的这些值分别为1.05（95%CI，0.95 - 1.16）和1.12（95%CI，1.02 - 1.23）。
在明显的心电图左心室肥厚出现之前，血压升高可能导致心室去极化和复极化紊乱。
