Begasse F, Chamontin B, Fonquernie L, Didier A, Chollet P, Leophonte P, Salvador M
Service de médecine interne et d'hypertension artérielle, CHU, Toulouse-Purpan.
Arch Mal Coeur Vaiss. 1991 Aug;84(8):1133-6.
The frequent association of sleep apnea syndrome and essential hypertension led to think of sleep apnea as an etiology of hypertension, especially as a good correlation has been found between the severity of both diseases. Moreover, treating the apnea syndrome results in a decrease of blood pressure. The aim of our study is to depict the outlines of a severe hypertensive individual with sleep apnea by comparing 9 men primarily referred to the hypertension clinic with refractory hypertension and finally found to have sleep apnea (study group) to 23 men whose diagnosis of sleep apnea was made in the pulmonary unit (controls). Fifteen of these were hypertensives. Mean age of the study group was 47 +/- 7 years vs 60 +/- 11. Controls were less overweighted: BMI = 33 +/- 6 kg/m3 vs 39 +/- 5. Mean blood pressure was 171 +/- 16/107 +/- 4 mmHg in the study group vs 157 +/- 19/92 +/- 12 mmHg in controls. Prevalence of glucose metabolism disorders was significantly greater in the study group: 6 patients with maturity onset diabetes and 3 with proven glucose intolerance, vs respectively 4 and 6 controls. Triglycerides were elevated in both groups whereas mean cholesterol was slightly above normal values. Six patients of the study group could have an echocardiogram which showed left ventricular hypertrophy (mean left ventricular mass index = 206 +/- 31 g/m2 after the Penn convention).(ABSTRACT TRUNCATED AT 250 WORDS)
睡眠呼吸暂停综合征与原发性高血压的频繁关联促使人们将睡眠呼吸暂停视为高血压的一个病因,尤其是因为已发现这两种疾病的严重程度之间存在良好的相关性。此外,治疗呼吸暂停综合征会导致血压下降。我们研究的目的是通过比较9名最初因难治性高血压被转诊至高血压诊所最终被发现患有睡眠呼吸暂停的男性(研究组)和23名在肺部科室被诊断为睡眠呼吸暂停的男性(对照组),来描绘一名患有睡眠呼吸暂停的重度高血压患者的概况。对照组中有15人患有高血压。研究组的平均年龄为47±7岁,对照组为60±11岁。对照组超重情况较轻:体重指数(BMI)=33±6kg/m³,研究组为39±5。研究组的平均血压为171±16/107±4mmHg,对照组为157±19/92±12mmHg。研究组葡萄糖代谢紊乱的患病率显著更高:6例成年发病型糖尿病患者和3例经证实的葡萄糖耐量异常患者,对照组分别为4例和6例。两组甘油三酯均升高,而平均胆固醇略高于正常值。研究组中有6名患者进行了超声心动图检查,结果显示左心室肥厚(根据宾夕法尼亚标准,平均左心室质量指数=206±31g/m²)。(摘要截断于250字)