Fletcher E C, DeBehnke R D, Lovoi M S, Gorin A B
Ann Intern Med. 1985 Aug;103(2):190-5. doi: 10.7326/0003-4819-103-2-190.
The prevalence of sleep apnea was studied in 46 middle- and older-aged men with "essential hypertension." Thirty-four age- and weight-similar normotensive men were also studied. Fourteen hypertensive men and three controls had sleep apnea syndrome, as defined as greater than ten apneas per hour of sleep. Hypertensive men with apnea tended to be more overweight and slightly older than the hypertensive men without apnea, but differences were not statistically significant. Individual men with apnea could not be distinguished by their answers on a questionnaire that elicited symptoms related to apnea. Seven hypertensive men with apnea were treated with protriptyline and one with uvulopalatopharyngoplasty, and apnea index (apneas per hour) decreased by 77% from pretreatment levels while mean blood pressure decreased from 149/95 mm Hg to 139/90 mm Hg. Undiagnosed sleep apnea syndrome may be associated with systemic hypertension in many middle- and older-aged men. In some, sleep apnea syndrome could be the cause of hypertension, and in others it may contribute to hypertension of another cause.
对46名患有“原发性高血压”的中老年男性的睡眠呼吸暂停患病率进行了研究。还对34名年龄和体重相仿的血压正常男性进行了研究。14名高血压男性和3名对照者患有睡眠呼吸暂停综合征，定义为每小时睡眠中呼吸暂停超过10次。患有呼吸暂停的高血压男性往往比没有呼吸暂停的高血压男性更超重且年龄稍大，但差异无统计学意义。通过一份引发与呼吸暂停相关症状的问卷回答，无法区分患有呼吸暂停的个体男性。7名患有呼吸暂停的高血压男性接受了普罗替林治疗，1名接受了悬雍垂腭咽成形术，呼吸暂停指数（每小时呼吸暂停次数）较治疗前水平下降了77%，同时平均血压从149/95毫米汞柱降至139/90毫米汞柱。未被诊断出的睡眠呼吸暂停综合征可能与许多中老年男性的系统性高血压有关。在一些人中，睡眠呼吸暂停综合征可能是高血压的病因，而在另一些人中，它可能导致由其他原因引起的高血压。
