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自我报告伤口愈合受损个体的免疫适应性、偏头痛及头痛主诉

Immune Fitness, Migraine, and Headache Complaints in Individuals with Self-Reported Impaired Wound Healing.

作者信息

Balikji Jessica, Mackus Marlou, Garssen Johan, Hoogbergen Maarten M, Verster Joris C

机构信息

Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, 3584 CG, the Netherlands.

Division of Plastic Surgery, Catharina Ziekenhuis, Eindhoven, 5623 EJ, the Netherlands.

出版信息

Int J Gen Med. 2023 Jun 3;16:2245-2253. doi: 10.2147/IJGM.S413258. eCollection 2023.

Abstract

BACKGROUND

Having chronic wounds and impaired wound healing are associated with psychological distress. The current study aims to evaluate migraine and headache complaints in young adults with self-reported impaired wound healing.

METHODS

A survey was conducted among N=1935 young adults (83.6% women), 18-30 years old, living in the Netherlands. Wound healing status was verified, immune fitness was assessed using a single-item rating scale, and ID Migraine was completed. In addition, several questions were answered on past year's headache experiences (including frequency, quantity, type, location, and severity).

RESULTS

In both the control group ( < 0.001) and the IWH group ( = 0.002) immune fitness was significantly lower among those that reported headaches compared to those that reported no headaches. Individuals with self-reported impaired wound healing (IWH) scored significantly higher on the ID Migraine scale, and individuals of the IWH group scored significantly more often positive for migraine (ie, an ID Migraine score ≥2). They reported a younger age of onset of experiencing headaches, and significantly more often reported having a beating or pounding headache than the control group. Compared to the control group, the IWH group reported being significantly more limited in their daily activities compared to the control group.

CONCLUSION

Headaches and migraines are more frequently reported by individuals with self-reported impaired wound healing, and their reported immune fitness is significantly poorer compared to healthy controls. These headache and migraine complaints significantly limit them in their daily activities.

摘要

背景

患有慢性伤口和伤口愈合受损与心理困扰有关。本研究旨在评估自我报告伤口愈合受损的年轻人中的偏头痛和头痛症状。

方法

对居住在荷兰的1935名18至30岁的年轻人(83.6%为女性)进行了一项调查。核实伤口愈合状况,使用单项评分量表评估免疫健康状况,并完成国际头痛疾病分类(ICHD)偏头痛模块。此外,还回答了几个关于过去一年头痛经历的问题(包括频率、次数、类型、位置和严重程度)。

结果

在对照组(<0.001)和伤口愈合受损组(=0.002)中,报告有头痛的人的免疫健康状况明显低于报告无头痛的人。自我报告伤口愈合受损(IWH)的个体在ICHD偏头痛量表上得分显著更高,IWH组的个体偏头痛呈阳性(即ICHD偏头痛评分≥2)的频率显著更高。他们报告头痛发作的年龄更小,与对照组相比,报告有搏动性或跳痛性头痛的频率显著更高。与对照组相比,IWH组报告其日常活动受到的限制明显更大。

结论

自我报告伤口愈合受损的个体更频繁地报告头痛和偏头痛,与健康对照组相比,他们报告的免疫健康状况明显更差。这些头痛和偏头痛症状严重限制了他们的日常活动。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f199/10246567/b822427dc793/IJGM-16-2245-g0001.jpg

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