Bürkle G, Bürkle H
Radiologische Abteilung des Kreiskrankenhauses, Donaueschingen.
Rofo. 1991 Nov;155(5):393-404. doi: 10.1055/s-2008-1033285.
551 angiographic therapeutic radiological interventions were studied in detail. They included 246 patients treated by local, low dose fibrinolysis with consecutive PTA, 55 interventions treated by fibrinolysis therapy alone and 250 patients treated by angioplasty. The results of low dose, low duration fibrinolysis with or without consecutive PTA was compared with the "standard" results from PTA despite the variations in the severity of the arterial occlusive disease. The indications for local fibrinolysis are discussed and the variations from the technique reported in the literature are described ("retrograde" local fibrinolysis). We have not been able to show any statistical relationship between clot lysis and duration of history or the length of vascular occlusion. Clinical improvement of at least one stage (according to Fontaine) was achieved in 85% of cases by PTA, 60% by local lysis and 74% by lysis with subsequent PTA.
对551例血管造影治疗性放射学干预进行了详细研究。其中包括246例接受局部低剂量纤维蛋白溶解并连续进行经皮腔内血管成形术（PTA）治疗的患者、55例仅接受纤维蛋白溶解疗法治疗的干预措施以及250例接受血管成形术治疗的患者。尽管动脉闭塞性疾病的严重程度存在差异，但仍将低剂量、短疗程纤维蛋白溶解联合或不联合连续PTA的结果与PTA的“标准”结果进行了比较。讨论了局部纤维蛋白溶解的适应症，并描述了与文献报道技术的差异（“逆行”局部纤维蛋白溶解）。我们未能发现血栓溶解与病史时长或血管闭塞长度之间存在任何统计学关系。通过PTA，85%的病例实现了至少一个阶段（根据Fontaine分级）的临床改善；通过局部溶解，60%的病例实现了临床改善；通过溶解后进行PTA，74%的病例实现了临床改善。
