Zhang Qin, Ma Bangyi, Fischman Alan J, Tompkins Ronald G, Carter Edward A
Department of Surgery, Massachusetts General Hospital, and Shriners Hospital for Children, Boston, MA 02114, USA.
J Burn Care Res. 2008 Mar-Apr;29(2):358-62. doi: 10.1097/BCR.0b013e318166739c.
Brown adipose tissue (BAT) contains numerous mitochondria and is characterized by the presence of uncoupling protein 1 (UCP1). UCP1 is the main mediator of thermogenesis that plays an important role in the modulation of energy balance. The authors hypothesize that alterations in the expression of UCP1 might be involved in the major metabolic disorders occurring during burn trauma. The present study is designed to explore the potential role of the UCP1 in metabolic disorders after burn injury. The authors have used the real-time reverse transcription-polymerase chain reaction to quantify UCP1 mRNA expression in the mice BAT and white adipose tissue (WAT). UCP1 mRNA expression was up-regulated in BAT, especially at 24 hours after burn. UCP1 mRNA expression was detectable and also up-regulated by burn injury in WAT. The authors provide evidence that one of the mechanisms mediating hypermetabolism and increased energy expenditure in burn injury is a pronounced increase in thermogenic capacity, as illustrated by robust gene expression of UCP1 in BAT and WAT.
棕色脂肪组织（BAT）含有大量线粒体，其特征是存在解偶联蛋白1（UCP1）。UCP1是产热的主要介质，在能量平衡调节中起重要作用。作者推测，UCP1表达的改变可能与烧伤创伤期间发生的主要代谢紊乱有关。本研究旨在探讨UCP1在烧伤后代谢紊乱中的潜在作用。作者使用实时逆转录-聚合酶链反应来定量小鼠BAT和白色脂肪组织（WAT）中UCP1 mRNA的表达。UCP1 mRNA表达在BAT中上调，尤其是在烧伤后24小时。UCP1 mRNA表达在WAT中可检测到，并且也因烧伤损伤而上调。作者提供的证据表明，介导烧伤后高代谢和能量消耗增加的机制之一是产热能力的显著增加，如BAT和WAT中UCP1的强劲基因表达所示。
