Wardrop Douglas, Keeling David
Oxford Haemophilia and Thrombosis Centre, Oxford Radcliffe Hospitals, Oxford, UK.
Br J Haematol. 2008 Jun;141(6):757-63. doi: 10.1111/j.1365-2141.2008.07119.x. Epub 2008 Mar 18.
Heparin and coumarins have been the mainstay of anticoagulant therapy throughout our working lives. As we stand on the threshold of a new era of anticoagulants it is timely to look back upon their discovery and development. Both have fascinating stories to tell. Jay McLean claimed to have discovered heparin whilst a medical student, although this is disputed. The story of warfarin leads us from a mysterious haemorrhagic disease of cattle to the development of a rat poison which became one of the most commonly prescribed drugs in history. Many people were involved in both stories and we owe them all a debt of gratitude.
在我们整个职业生涯中，肝素和香豆素一直是抗凝治疗的中流砥柱。当我们站在抗凝剂新时代的门槛上时，适时回顾一下它们的发现和发展历程是很有必要的。两者都有引人入胜的故事。杰伊·麦克莱恩声称自己还是一名医学生时就发现了肝素，不过这一说法存在争议。华法林的故事则引领我们从一种神秘的牛出血性疾病，到一种灭鼠药的研发，而这种灭鼠药后来成为了历史上最常用的处方药之一。这两个故事都涉及了许多人，我们都欠他们一份感激之情。
