Bagić A, Theodore W H, Boudreau E A, Bonwetsch R, Greenfield J, Elkins W, Sato S
EEG Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD, USA.
Acta Neurol Scand. 2008 Oct;118(4):240-4. doi: 10.1111/j.1600-0404.2008.01008.x. Epub 2008 Mar 18.
To evaluate the feasibility and safety of head-neck cooling in conscious normal volunteers (10) and patients with medically refractory epilepsy (5) without causing shivering.
We used a non-invasive head-neck cooling system (CoolSystems Inc., Lincoln, CA, USA). The tympanic temperature (TT) and intestinal temperature (IT) were measured as two measurements of 'core temperature' (CT), and multi-site external temperatures, several physiologic variables and EEG were monitored. Seizure counts over 4-week precooling, treatment and follow-up phases were compared.
All 15 participants completed all the cooling sessions without significant complaints. At the end of 60 min of cooling, scalp temperature fell on average by 12.2 degrees C (P < 0.001), TT by 1.67 degrees C (P < 0.001), and IT by 0.12 degrees C (P = NS). Average weekly seizure frequency decreased from 2.7 to 1.7 events per patient per week (MANOVA: P < 0.05).
Non-invasive head-neck cooling is safe and well-tolerated. Initial pilot data in patients suggest that additional therapeutic studies are warranted.
评估对头颈部进行冷却在清醒的正常志愿者（10名）和药物难治性癫痫患者（5名）中不引起寒战的可行性和安全性。
我们使用了一种非侵入性头颈部冷却系统（美国加利福尼亚州林肯市CoolSystems公司）。测量鼓膜温度（TT）和肠道温度（IT）作为“核心温度”（CT）的两种测量指标，并监测多个部位的体表温度、多个生理变量和脑电图。比较了预冷却、治疗和随访4周期间的癫痫发作次数。
所有15名参与者均完成了所有冷却疗程，且无明显不适主诉。冷却60分钟结束时，头皮温度平均下降12.2摄氏度（P<0.001），TT下降1.67摄氏度（P<0.001），IT下降0.12摄氏度（P=无统计学意义）。每位患者每周的癫痫发作平均频率从2.7次降至1.7次（多变量方差分析：P<0.05）。
非侵入性头颈部冷却是安全且耐受性良好的。患者的初步试验数据表明有必要进行更多的治疗研究。
