Yang Jun, Yang Yu, Chen Jian-Min, Liu Wen-Yan, Lin Bao-Chen
Institute for Pharmaceuticals and Medical Science, Guangdong Bangmin Pharmaceutical Co. Ltd., Jianhai Distract, Jianmen, Guangdong, China.
Brain Res Bull. 2008 Mar 28;75(5):681-6. doi: 10.1016/j.brainresbull.2007.11.004. Epub 2007 Dec 3.
Hypothalamic supraoptic nucleus (SON) has been demonstrated to involve in pain modulation. Acupuncture analgesia is a very useful clinical skill for pain relief, which has over 2500-year history in China. The present study investigated the effect of SON on acupuncture analgesia in the rat. Electrical stimulation of the SON or microinjection of a small dose L-glutamate sodium into the SON enhanced acupuncture analgesia in a dose-dependent manner, while cauterization of the SON weakened acupuncture analgesia. Pituitary removal did not influence the effect of L-glutamate sodium that enhanced acupuncture analgesia in the SON. The data suggested that the neurons and not the nerve fibers in the SON played an important role in acupuncture analgesia, which effect might be through the central nervous system rather than the hypothalamo-neurohypophyseal system.
下丘脑视上核（SON）已被证明参与疼痛调节。针刺镇痛是一种非常有效的缓解疼痛的临床技术，在中国已有2500多年的历史。本研究调查了视上核在大鼠针刺镇痛中的作用。电刺激视上核或向视上核微量注射小剂量L-谷氨酸钠可剂量依赖性地增强针刺镇痛作用，而对视上核进行烧灼则会减弱针刺镇痛作用。摘除垂体并不影响L-谷氨酸钠增强视上核针刺镇痛的效果。数据表明，视上核中的神经元而非神经纤维在针刺镇痛中起重要作用，其作用可能是通过中枢神经系统而非下丘脑-神经垂体系统。
