d'Amore F, Christensen B E, Brincker H, Pedersen N T, Thorling K, Hastrup J, Pedersen M, Jensen M K, Johansen P, Andersen E
Department of Haematology, Odense University Hospital, Denmark.
Eur J Cancer. 1991;27(10):1201-8. doi: 10.1016/0277-5379(91)90081-n.
In a Danish population-based non-Hodgkin lymphoma (NHL) registry, 1257 newly diagnosed NHL cases were registered over a 5-year period. Of these, 463 (37%) were extranodal. The gastrointestinal tract was the most common site of extranodal involvement (30% of the cases). Histologically, 44% of all extranodal NHL cases had high-grade, 17% intermediate and 27% low-grade features, while 12% were unclassified. The most common histological subtype (Kiel) was the centroblastic diffuse (23% of cases). 50% of all extranodal NHL were localised (stage IE or IIE) and 27% had B symptoms. Site-specific features included a strong age-correlation for thyroid and testes lymphoma (greater than 50 years) and a high prevalence of female cases in thyroid and salivary glands lymphomas (M/F 0.14 and 0.30, respectively). Overall 7-year survival for extranodal NHL was 46% (median 4.9 years). Poor prognosis patients could be identified by the presence of one or more of the following presentation characteristics: age greater than 65 years, B symptoms, high-grade histology, disseminated disease, elevated s-IgA and hyperuricaemia. Relative risk values ranged from 2.1 for age and B symptoms to 1.7 for hyperuricaemia.
在丹麦一项基于人群的非霍奇金淋巴瘤（NHL）登记中，5年期间登记了1257例新诊断的NHL病例。其中，463例（37%）为结外淋巴瘤。胃肠道是结外受累最常见的部位（占病例的30%）。组织学上，所有结外NHL病例中44%具有高级别特征，17%为中级别，27%为低级别特征，而12%未分类。最常见的组织学亚型（ Kiel分类）是中心母细胞弥漫型（占病例的23%）。所有结外NHL中50%为局限性（IE期或IIE期），27%有B症状。特定部位的特征包括甲状腺和睾丸淋巴瘤与年龄有很强的相关性（大于50岁），以及甲状腺和唾液腺淋巴瘤女性病例的高患病率（男女比例分别为0.14和0.30）。结外NHL的总体7年生存率为46%（中位生存期4.9年）。预后不良的患者可通过以下一种或多种表现特征来识别：年龄大于65岁、B症状、高级别组织学、播散性疾病、血清IgA升高和高尿酸血症。相对风险值范围从年龄和B症状的2.1到高尿酸血症的1.7。
