Santangelo Giusi, Palaia Innocenza, Perniola Giorgia, Di Pinto Anna, Musella Angela, Tomao Federica, Fischetti Margherita, Sassu Carolina, Piccioni Mariagrazia, Di Donato Violante, Benedetti Panici Pierluigi
Department of Maternal and Child Health and Urological Sciences, Policlinico "Umberto I", University "Sapienza", Viale del Policlinico, 155, 00161, Rome, Italy.
J Med Case Rep. 2020 Sep 2;14(1):138. doi: 10.1186/s13256-020-02487-6.
Mantle cell lymphoma is one of several subtypes of non-Hodgkin lymphoma. Cervical relapse of non-Hodgkin lymphoma is a very rare condition that has a variable and nonspecific presentation and may resemble other neoplastic or inflammatory conditions.
Our patient was a 58-year-old Caucasian woman who experienced relapse of mantle cell lymphoma with cervical localization. She complained of postmenopausal vaginal bleeding, bladder pressure, and rapid growth of a cervical lesion. An irregular tumor mass of the cervix was visualized during gynecological examination, with findings highly suggestive of locally advanced cervical cancer. Surprisingly, the biopsies showed an extra nodal relapse of mantle cell lymphoma in the cervix. The rarity of this presentation and the scarcity of clinical studies make this type of recurrence very aggressive and difficult to treat.
Obtaining a definitive histological diagnosis by biopsy or surgical resection and starting appropriate therapy are essential for recovery and treatment of these patients, even if the prognosis is poor.
套细胞淋巴瘤是非霍奇金淋巴瘤的几种亚型之一。非霍奇金淋巴瘤的颈部复发是一种非常罕见的情况，其表现多样且不具特异性，可能类似于其他肿瘤性或炎症性疾病。
我们的患者是一名58岁的白种女性，出现了套细胞淋巴瘤颈部复发。她主诉绝经后阴道出血、膀胱压迫感以及宫颈肿物迅速生长。妇科检查时可见宫颈有不规则肿瘤肿块，检查结果高度提示局部晚期宫颈癌。令人惊讶的是，活检显示宫颈为套细胞淋巴瘤的结外复发。这种表现的罕见性以及临床研究的匮乏使得这种类型的复发极具侵袭性且难以治疗。
通过活检或手术切除获得明确的组织学诊断并开始适当的治疗对于这些患者的康复和治疗至关重要，即便预后不佳。
