Udeinya J I, Shu E N, Quakyi I, Ajayi F O
Rocitus Institute of Research, Enugu, Nigeria.
Am J Ther. 2008 Mar-Apr;15(2):108-10. doi: 10.1097/MJT.0b013e31804c6d1d.
A crude acetone/water (50/50) extract of neem leaves (IRAB) was evaluated for activity against the asexual (trophozoites/schizonts) and the sexual (gametocytes) forms of the malarial parasite, Plasmodium falciparum, in vitro. In separate 72 hour cultures of both asexual parasites and mature gametocytes treated with IRAB (0.5 microg/mL), parasite numbers were less than 50% of the numbers in control cultures, which had 8.0% and 8.5% parasitemia, respectively. In cultures containing 2.5 microg/mL, asexual parasites and mature and immature gametocytes were reduced to 0.1%, 0.2%, and 0% parasitemia, respectively. There were no parasites in the cultures containing 5.0 microg/mL. This extract, if found safe, may provide materials for development of new antimalarial drugs that may be useful both in treatment of malaria as well as the control of its transmission through gametocytes.
对印楝叶的粗制丙酮/水（50/50）提取物（IRAB）进行了体外抗恶性疟原虫无性体（滋养体/裂殖体）和有性体（配子体）活性的评估。在用IRAB（0.5微克/毫升）处理的无性寄生虫和成熟配子体的单独72小时培养物中，寄生虫数量分别低于对照培养物中数量的50%，对照培养物的疟原虫血症分别为8.0%和8.5%。在含有2.5微克/毫升的培养物中，无性寄生虫以及成熟和未成熟配子体的疟原虫血症分别降至0.1%、0.2%和0%。含有5.0微克/毫升的培养物中没有寄生虫。如果该提取物被证明是安全的，可能会为开发新的抗疟药物提供材料，这些药物可能对疟疾治疗以及通过配子体控制疟疾传播都有用。
