Grönfors T, Pyykkö I, Aalto H, Juhola M, Ishizaki H
Department of Computer Science, University of Turku, Finland.
Med Prog Technol. 1991;17(2):119-28.
We have designed and implemented a microcomputer system for studying the effect of various mediator substances on the nasal blood flow. The system uses an IBM PC/AT microcomputer, which is connected with a Laser Doppler Flowmeter (LDF) and an iontophoretic drug application system. The LDF measures flux from the tissue that in the example is the inferior nasal turbinate. The flux is converted to digital form by an analog-digital converter of 12 bits. The program is implemented in the Pascal language. In the analysis, a flux level, amplitude, rise time and decay time of the pulse wave are determined. The effect of drugs on the flux can be studied by applying them iontophoretically. In the program the length and number of the drug application periods as well as the recording period are user-driven. In the nasal blood flow iontophoretically administered adrenaline reduced significantly the flux parameters and histamine canceled this effect. Tachyphylalaxis was a frequent observation in repeated measurements. The system can be used to evaluate the role of different transmitters in the etiology of chronic rhinitis.
我们设计并实现了一个用于研究各种介质物质对鼻血流影响的微型计算机系统。该系统使用一台IBM PC/AT微型计算机，它与激光多普勒血流仪（LDF）和离子电渗药物应用系统相连。LDF测量来自组织（在该示例中为下鼻甲）的血流量。血流量通过一个12位的模拟数字转换器转换为数字形式。该程序用Pascal语言实现。在分析中，确定脉搏波的血流量水平、幅度、上升时间和衰减时间。可以通过离子电渗法应用药物来研究药物对血流量的影响。在程序中，药物应用期的长度和次数以及记录期均由用户驱动。在鼻血流中，离子电渗给予的肾上腺素显著降低了血流量参数，而组胺消除了这种作用。在重复测量中经常观察到快速耐受性。该系统可用于评估不同递质在慢性鼻炎病因学中的作用。
