Doorenbos C J
Department of Nephrology and Hypertension, University Hospital, Leiden, The Netherlands.
Neth J Med. 1991 Aug;39(1-2):28-44.
In the past several years great progress has been made in the understanding of the (patho) physiology of ANP. Because an inhibitor of ANP is not available for human use, there is still discussion about the physiological role of ANP. Nevertheless, from the studies described above the evidence is accumulating that ANP has a role in protecting against fluid overload and hypertension by means of inducing natriuresis, inhibition of the renin-angiotensin-aldosterone system and vasopressin and by vasodilation. The therapeutic potential of modulation of the ANP system seems promising, but must await further research.
在过去几年里，人们对心钠素（ANP）的（病理）生理学的理解取得了巨大进展。由于尚无用于人类的ANP抑制剂，关于ANP的生理作用仍存在争议。然而，从上述研究中积累的证据表明，ANP通过诱导利钠作用、抑制肾素-血管紧张素-醛固酮系统和抗利尿激素以及通过血管舒张，在预防液体超负荷和高血压方面发挥作用。调节ANP系统的治疗潜力似乎很有前景，但必须等待进一步的研究。
