Jovanović O
University Children's Hospital, Belgrade.
Srp Arh Celok Lek. 1993 Jan-Feb;121(1-2):25-8.
The aim of this review is to summarize current knowledge about atrial natriuretic peptide (ANP)--its structure, secretion and target organ actions. Due to enormous researches, this review is a summary with special emphasis to the physiologic importance of ANP in humans. In the kidney ANP acts on specific receptors inducing hyperfiltration inhibition of sodium transport and suppression of renin release, effects responsible for natriuresis and diuresis. ANP also lowers blood pressure by inhibiting aldosterone biosynthesis and facilitates transudation of plasma water to interstitium. The current knowledge of ANP physiology is based on the study of blood levels and renal effects of ANP in the presence of different manipulations (variations in dietary sodium intake, posture, water immersion, infusion of synthetic ANP). In healty humans ANP levels rise in response to intravenous loading with saline, by acute dietary sodium overload or by immersion of the body into water. Considering these reactions it is possible that ANP helps to protect the heart from volume overload.
本综述的目的是总结目前关于心房利钠肽（ANP）的知识——其结构、分泌及对靶器官的作用。由于已有大量研究，本综述在总结时特别强调了ANP在人类生理方面的重要性。在肾脏中，ANP作用于特定受体，抑制超滤、钠转运并抑制肾素释放，这些效应导致利钠和利尿。ANP还通过抑制醛固酮生物合成来降低血压，并促进血浆水向间质的渗出。目前关于ANP生理学的知识基于在不同操作（饮食中钠摄入量变化、体位、水浸、输注合成ANP）情况下对ANP血药浓度及肾脏效应的研究。在健康人类中，静脉输注生理盐水、急性饮食性钠超载或身体浸入水中会使ANP水平升高。考虑到这些反应，ANP有可能有助于保护心脏免受容量超载的影响。
