[硫氧还蛋白的生物学及其与阿尔茨海默病和帕金森病的关联]
[Biology of thioredoxin and its association with Alzheimer's disease and Parkinson's disease].
作者信息
Li Li-Bo, Liu Geng-Tao
机构信息
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
出版信息
Yao Xue Xue Bao. 2008 Jan;43(1):1-8.
Thioredoxin (Trx) is a crucial protein for antioxidative defense, as well as a redox regulator of the intra- and extracellular signaling pathways and transcription factors. In this review, we focus on mammalian Trx and its association with Alzheimer's disease (AD) and Parkinson's disease (PD). Based on the evidence of neuroprotective effects of Trx, up-regulation of Trx may be a good strategy for prevention and treatment of AD and PD.
硫氧还蛋白（Trx）是抗氧化防御的关键蛋白，也是细胞内和细胞外信号通路及转录因子的氧化还原调节剂。在本综述中，我们聚焦于哺乳动物硫氧还蛋白及其与阿尔茨海默病（AD）和帕金森病（PD）的关联。基于硫氧还蛋白具有神经保护作用的证据，上调硫氧还蛋白可能是预防和治疗阿尔茨海默病和帕金森病的一个良好策略。
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