Moore Alicia B, Flake Gordon P, Swartz Carol D, Heartwell Glenn, Cousins Deborah, Haseman Joseph K, Kissling Grace E, Sidawy Mary K, Dixon Darlene
Laboratory of Experimental Pathology and Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.
J Reprod Med. 2008 Feb;53(2):90-6.
To determine the associations of race, age and body mass index (BMI) with the gross pathology parameters of uterine leiomyomas in premenopausal women undergoing hysterectomy or myomectomy.
Participants (N = 107) were recruited from surgical rosters of the George Washington University (GWU) Medical Center Gynecology Department as part of the National Institute of Environmental Health Sciences Fibroid Study. Tumor data and patient demographics were obtained from clinical reports, pathology forms and interviews.
Surgical cases consisted of 78% African Americans, 13% Caucasians and 9% others (non-African American, non-Caucasian or race unknown). This proportion of African Americans was significantly higher than the distribution of GWU health plan participants. Fibroids were localized predominantly within the intramural region. Subserosal tumors were more common in patients with more than 9 tumors. African Americans had the highest mean BMI and mean myomatous uterine weight.
African Americans were the disproportionate majority coming to surgery for fibroids. The average BMI and uterine weight were greater in African Americans than in Caucasians, although these differences were marginal. Race did not influence the size, location or number of fibroids in these surgical cases. Subserosal tumors were more common in patients with more than 9 tumors.
确定种族、年龄和体重指数（BMI）与接受子宫切除术或肌瘤切除术的绝经前女性子宫平滑肌瘤大体病理参数之间的关联。
作为美国国立环境卫生科学研究所肌瘤研究的一部分，从乔治华盛顿大学（GWU）医学中心妇科手术登记册中招募了参与者（N = 107）。肿瘤数据和患者人口统计学信息来自临床报告、病理表格和访谈。
手术病例包括78%的非裔美国人、13%的白种人和9%的其他种族（非非裔美国人、非白种人或种族不明）。非裔美国人的这一比例显著高于GWU健康计划参与者的分布比例。肌瘤主要位于肌壁间区域。浆膜下肿瘤在有9个以上肿瘤的患者中更为常见。非裔美国人的平均BMI和肌瘤子宫平均重量最高。
非裔美国人是因肌瘤前来手术的不成比例的多数群体。非裔美国人的平均BMI和子宫重量高于白种人，尽管这些差异很小。种族并未影响这些手术病例中肌瘤的大小、位置或数量。浆膜下肿瘤在有9个以上肿瘤的患者中更为常见。
