Dymling S O, Persson H W, Hertz C H
Department of Electrical Measurements, Lund Institute of Technology, Sweden.
Ultrasound Med Biol. 1991;17(5):433-44. doi: 10.1016/0301-5629(91)90179-z.
A diagnostic tool for noninvasive evaluation of microcirculatory blood flow using continuous-wave CW Doppler ultrasound is presented. In this study, the properties of this method are investigated both theoretically and experimentally. The method utilizes a nondirectional CW Doppler flowmeter. Blood perfusion in tissue is shown to be proportional to the integral integral of fS (f)df where S(f) is the Doppler power spectrum and f is the Doppler frequency. The instrumentation needed to implement the method is described. Using an experimental flow model it is demonstrated that the above integral is proportional to the product between the number of scatterers in the sample volume of the Doppler probe and the mean speed of these scatterers. This is true even for low flow velocities (down to 1 mm/s). The results from in-vivo measurements on tissues in the finger, and the calf demonstrate that the method can monitor changes in the blood perfusion. It also shows the present limitations of the method due to movement artefacts.
介绍了一种使用连续波（CW）多普勒超声对微循环血流进行无创评估的诊断工具。在本研究中，从理论和实验两方面对该方法的特性进行了研究。该方法使用了一种非定向CW多普勒流量计。组织中的血液灌注与fS(f)df的积分成正比，其中S(f)是多普勒功率谱，f是多普勒频率。描述了实施该方法所需的仪器设备。使用实验血流模型证明，上述积分与多普勒探头采样体积内散射体的数量和这些散射体的平均速度的乘积成正比。即使对于低流速（低至1毫米/秒）也是如此。对手指和小腿组织的体内测量结果表明，该方法可以监测血液灌注的变化。它还显示了由于运动伪影导致的该方法目前的局限性。
