Holden Karen F, Lindquist Karla, Tylavsky Frances A, Rosano Caterina, Harris Tamara B, Yaffe Kristine
Department of Psychiatry, University of California San Francisco, 94143, USA.
Neurobiol Aging. 2009 Sep;30(9):1483-9. doi: 10.1016/j.neurobiolaging.2007.11.024. Epub 2008 Mar 20.
Leptin is a peptide hormone secreted by adipocytes. It has been shown to modulate production and clearance of amyloid beta (Abeta) in rodent models. We sought to determine if serum leptin was associated with cognitive decline in the elderly. We studied 2871 well-functioning elders, aged 70-79, who were enrolled in a prospective study. Serum leptin concentrations were measured at baseline and analyzed by mean+/-1S.D. Clinically significantly cognitive decline over 4 years was defined as > or =5-point drop on the Modified Mini Mental State Exam (3MS). Compared to those in the lower leptin groups, elders in the high leptin group had less cognitive decline, 20.5% versus 24.7% (OR=0.79; 95% CI 0.61-1.02, p=0.07). After adjustment for demographic and clinical variables, including body mass index and total percent body fat, those in the high leptin group had significantly less likelihood of cognitive decline, OR=0.66 (95% CI 0.48-0.91). We conclude that in elderly individuals, higher serum leptin appears to protect against cognitive decline, independent of comorbidites and body fat.
瘦素是一种由脂肪细胞分泌的肽类激素。在啮齿动物模型中，它已被证明可调节β淀粉样蛋白（Aβ）的产生和清除。我们试图确定血清瘦素是否与老年人的认知衰退有关。我们研究了2871名70至79岁功能良好的老年人，他们参与了一项前瞻性研究。在基线时测量血清瘦素浓度，并以均值±1标准差进行分析。4年内临床上显著的认知衰退定义为改良简易精神状态检查表（3MS）得分下降≥5分。与瘦素水平较低组的老年人相比，高瘦素组的老年人认知衰退较少，分别为20.5%和24.7%（比值比=0.79；95%置信区间0.61-1.02，p=0.07）。在对人口统计学和临床变量进行调整后，包括体重指数和体脂百分比，高瘦素组的老年人认知衰退的可能性显著降低，比值比=0.66（95%置信区间0.48-0.91）。我们得出结论，在老年人中，较高的血清瘦素似乎可预防认知衰退，且独立于合并症和体脂。
