GATA-3与乳腺管腔细胞命运的调控
GATA-3 and the regulation of the mammary luminal cell fate.
作者信息
Kouros-Mehr Hosein, Kim Jung-whan, Bechis Seth K, Werb Zena
机构信息
Department of Anatomy and the Biomedical Sciences Program, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0452, United States.
出版信息
Curr Opin Cell Biol. 2008 Apr;20(2):164-70. doi: 10.1016/j.ceb.2008.02.003. Epub 2008 Mar 21.
Abstract
The GATA family of transcription factors plays essential roles in the specification and maintenance of differentiated cell types. GATA-3 was identified in a microarray screen of the mouse mammary gland as the most highly expressed transcription factor in the mammary epithelium and is expressed exclusively in the luminal epithelial cell population. Targeted deletion of GATA-3 in mammary glands leads to profound defects in mammary development and inability to specify and maintain the luminal cell fate in the adult mouse. In breast cancer, GATA-3 has emerged as a strong predictor of tumor differentiation, estrogen-receptor status, and clinical outcome. GATA-3 maintains tumor differentiation and suppresses tumor dissemination in a mouse model of breast cancer. This review explores our current understanding of GATA-3 signaling in luminal cell differentiation, both in mammary development and breast cancer.
摘要
转录因子GATA家族在分化细胞类型的特化和维持中发挥着重要作用。GATA-3在小鼠乳腺的微阵列筛选中被鉴定为乳腺上皮中表达最高的转录因子，且仅在腔上皮细胞群体中表达。乳腺中GATA-3的靶向缺失会导致乳腺发育的严重缺陷，并且无法在成年小鼠中特化和维持腔细胞命运。在乳腺癌中，GATA-3已成为肿瘤分化、雌激素受体状态和临床结果的有力预测指标。在乳腺癌小鼠模型中，GATA-3维持肿瘤分化并抑制肿瘤扩散。本综述探讨了我们目前对GATA-3信号在乳腺发育和乳腺癌腔细胞分化中的理解。
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本文引用的文献
1
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Cancer Cell. 2008 Feb;13(2):141-52. doi: 10.1016/j.ccr.2008.01.011.
2
Oestrogen-receptor-mediated transcription and the influence of co-factors and chromatin state.雌激素受体介导的转录以及辅助因子和染色质状态的影响。
Nat Rev Cancer. 2007 Sep;7(9):713-22. doi: 10.1038/nrc2211.
3
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch.对Gata3表达的直接调控决定了Notch的辅助性T细胞分化潜能。
Immunity. 2007 Jul;27(1):89-99. doi: 10.1016/j.immuni.2007.05.021. Epub 2007 Jul 19.
4
Notch directly regulates Gata3 expression during T helper 2 cell differentiation.Notch在辅助性T细胞2分化过程中直接调控Gata3的表达。
Immunity. 2007 Jul;27(1):100-10. doi: 10.1016/j.immuni.2007.04.018. Epub 2007 Jul 19.
5
Positive cross-regulatory loop ties GATA-3 to estrogen receptor alpha expression in breast cancer.正向交叉调节环将GATA-3与乳腺癌中的雌激素受体α表达联系起来。
Cancer Res. 2007 Jul 1;67(13):6477-83. doi: 10.1158/0008-5472.CAN-07-0746.
6
GATA-3 - not just for Th2 cells anymore.GATA-3——不再仅仅与辅助性T细胞2相关。
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7
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Oncogene. 2007 Aug 9;26(36):5204-13. doi: 10.1038/sj.onc.1210333. Epub 2007 Feb 19.
8
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9
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10
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Clin Cancer Res. 2006 Nov 1;12(21):6459-68. doi: 10.1158/1078-0432.CCR-06-1383.
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