Haag A, Knake S, Hamer H M, Boesebeck F, Freitag H, Schulz R, Baum P, Helmstaedter C, Wellmer J, Urbach H, Hopp P, Mayer T, Hufnagel A, Jokeit H, Lerche H, Uttner I, Meencke H-J, Meierkord H, Pauli E, Runge U, Saar J, Trinka E, Benke T, Vulliemoz S, Wiegand G, Stephani U, Wieser H G, Rating D, Werhahn K, Noachtar S, Schulze-Bonhage A, Wagner K, Alpherts W C J, Boas W van Emde, Rosenow F
Interdisciplinary Epilepsy Center at the University Hospitals Giessen and Marburg, Germany.
Epilepsy Behav. 2008 Jul;13(1):83-9. doi: 10.1016/j.yebeh.2008.02.012. Epub 2008 Mar 20.
Twenty-six Austrian, Dutch, German, and Swiss epilepsy centers were asked to report on use of the Wada test (intracarotid amobarbital procedure, IAP) from 2000 to 2005 and to give their opinion regarding its role in the presurgical diagnosis of epilepsy. Sixteen of the 23 centers providing information had performed 1421 Wada tests, predominantly the classic bilateral procedure (73%). A slight nonsignificant decrease over time in Wada test frequency, despite slightly increasing numbers of resective procedures, could be observed. Complication rates were relatively low (1.09%; 0.36% with permanent deficit). Test protocols were similar even though no universal standard protocol exists. Clinicians rated the Wada test as having good reliability and validity for language determination, whereas they questioned its reliability and validity for memory lateralization. Several noninvasive functional imaging techniques are already in use. However, clinicians currently do not want to rely solely on noninvasive functional imaging in all patients.
26个奥地利、荷兰、德国和瑞士的癫痫中心被要求报告2000年至2005年期间Wada试验（颈动脉内注射异戊巴比妥试验，IAP）的使用情况，并就其在癫痫术前诊断中的作用发表意见。提供信息的23个中心中有16个进行了1421次Wada试验，主要是经典的双侧试验（73%）。尽管切除手术数量略有增加，但随着时间的推移，Wada试验频率略有下降，但差异不显著。并发症发生率相对较低（1.09%；永久性缺陷发生率为0.36%）。尽管不存在通用的标准方案，但试验方案相似。临床医生认为Wada试验在语言判定方面具有良好的可靠性和有效性，而他们对其在记忆定侧方面的可靠性和有效性表示质疑。目前已经在使用几种无创功能成像技术。然而，临床医生目前并不想完全依赖于对所有患者进行无创功能成像。
