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特发性脊柱侧弯手术矫正后的住院并发症、死亡率及出院处置:全国性视角

Inpatient complications, mortality, and discharge disposition after surgical correction of idiopathic scoliosis: a national perspective.

作者信息

Patil Chirag G, Santarelli Justin, Lad Shivanand P, Ho Chris, Tian Wendy, Boakye Maxwell

机构信息

Department of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Drive Room R200, MC5327, Stanford, CA 94305, USA.

出版信息

Spine J. 2008 Nov-Dec;8(6):904-10. doi: 10.1016/j.spinee.2008.02.002. Epub 2008 Mar 20.

Abstract

BACKGROUND CONTEXT

Information about complications and mortality after surgery for correction of idiopathic scoliosis has been largely derived from single-institution series. Regional or national studies have been lacking.

PURPOSE

To report inpatient mortality, complications, and discharge disposition after surgical correction of idiopathic scoliosis on a national level.

STUDY DESIGN

Retrospective cohort study using National Inpatient Sample (NIS) administrative data.

PATIENT SAMPLE

All patients in the NIS with the primary diagnosis of idiopathic scoliosis who underwent a spinal fusion between 1993 and 2002 were included.

OUTCOME MEASURES

Inpatient complication rate, mortality rate, and adverse outcome defined by death or discharge to institution other than home.

METHODS

Outcome measures were abstracted from the NIS. Univariate and multivariate analyses were performed to analyze the effects of patient and hospital characteristics on outcome measures.

RESULTS

The NIS was used to identify 51,911 patients who underwent spinal fusion for idiopathic scoliosis in the United States from 1993 to 2002. The total inhospital complication rate was 14.9% for pediatric patients and 25.1% for adult patients. The inhospital mortality rate was 0.17% and 0.40% for pediatric and adult patients, respectively. Adverse outcome was noted in 2.3% of pediatric patients and 20.4% of adult patients. Pulmonary and postoperative hemorrhages/hematomas were the most common complications reported. Multivariate analysis for complications showed that morbidity was significantly lower for pediatric patients (odds ratio [OR] = 0.80; confidence interval [CI] = 0.68-0.94) and female patients (OR = 0.77; CI = 0.68-0.88). Patients with a preoperative comorbidity were 1.53 (CI = 1.32-1.76) times more likely to develop a complication. A single postoperative complication increased the mean length of stay by more than 2 days and increased the mortality rate, adverse outcome, and hospital charges significantly.

CONCLUSIONS

We have provided a national perspective on inpatient complications, mortality, and discharge disposition after spinal fusion for idiopathic scoliosis in the United States. The significant negative effects of postoperative complications on mortality and resource utilization have been demonstrated. Furthermore, we have identified adult age, male gender, and preoperative comorbidity as important risk factors and defined their impact on patient outcomes.

摘要

背景

有关特发性脊柱侧凸手术矫正后并发症和死亡率的信息大多来自单机构系列研究。缺乏区域或全国性研究。

目的

报告全国范围内特发性脊柱侧凸手术矫正后的住院死亡率、并发症及出院情况。

研究设计

使用国家住院样本(NIS)管理数据进行回顾性队列研究。

患者样本

纳入NIS中1993年至2002年间初次诊断为特发性脊柱侧凸并接受脊柱融合术的所有患者。

观察指标

住院并发症发生率、死亡率以及以死亡或出院至非家庭机构定义的不良结局。

方法

从NIS中提取观察指标。进行单因素和多因素分析以分析患者及医院特征对观察指标的影响。

结果

利用NIS识别出1993年至2002年间在美国接受特发性脊柱侧凸脊柱融合术的51,911例患者。儿科患者的总住院并发症发生率为14.9%,成人患者为25.1%。儿科和成人患者的住院死亡率分别为0.17%和0.40%。2.3%的儿科患者和20.4%的成人患者出现不良结局。肺部及术后出血/血肿是报告的最常见并发症。并发症的多因素分析显示,儿科患者(优势比[OR]=0.80;置信区间[CI]=0.68 - 0.94)和女性患者(OR = 0.77;CI = 0.68 - 0.88)的发病率显著较低。术前合并症患者发生并发症的可能性是无合并症患者的1.53倍(CI = 1.32 - 1.76)。单一术后并发症使平均住院时间延长超过2天,并显著增加死亡率、不良结局及住院费用。

结论

我们提供了美国特发性脊柱侧凸脊柱融合术后住院并发症、死亡率及出院情况的全国性视角。已证明术后并发症对死亡率和资源利用有显著负面影响。此外,我们确定了成年、男性性别及术前合并症为重要危险因素,并明确了它们对患者结局的影响。

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