Boakye Maxwell, Patil Chirag G, Santarelli Justin, Ho Chris, Tian Wendy, Lad Shivanand P
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, USA.
Neurosurgery. 2008 Feb;62(2):455-61; discussion 461-2. doi: 10.1227/01.neu.0000316013.97926.4c.
There is little information about in-hospital complication rates, adverse outcomes, and mortality after spinal fusion for cervical spondylotic myelopathy (CSM). The aim of this study was to report inpatient mortality, complications, and outcomes on a national level.
We used the National Inpatient Sample to identify 58,115 admissions of patients with CSM who underwent spinal fusion in the United States from 1993 to 2002. Multivariate analysis was performed to analyze the effects of patient and hospital characteristics on outcomes such as mortality, complications, discharge disposition, and length of stay.
A total of 58,115 patients with CSM underwent spinal fusion with an average mortality rate of 0.6%, a complication rate of 13.4%, and a mean length of stay of 4 days. Pulmonary (3.6%) and postoperative hemorrhages or hematomas (2.3%) were the most common complications reported. One postoperative complication led to a 4-day increase in mean length of stay, increased the mortality rate 20-fold, and added more than $10,000 to hospital charges. Multivariate analysis identified age, comorbidity, and admission type as the main predictors of mortality, complication rate, and adverse outcome. Patients aged > or =85 or 65 to 84 years had respective 44- and 14-fold increases in mortality, compared with patients in the 18- to 44-year age group. Patients older than 84 years had a 40-fold increase in adverse outcomes and a 5-fold likelihood of medical complications. Patients with three or more comorbidities had an increased risk of medical complications (odds ratio [OR], 1.98), adverse discharge (OR, 2.17), and in-hospital mortality (OR, 2.36). Elective admissions were associated with much lower rates of mortality (OR, 0.28), complication (OR, 0.68), and adverse outcome (OR, 0.26). Complications were greater for posterior fusion (16.4%) versus anterior fusion (11.9%) procedures. Anterior fusions were associated with a greater incidence of dysphagia (3%) and hoarseness (0.21%). Cervical spondylosis patients who presented without myelopathy had a much lower incidence of complications (6.3%).
We provide a national estimate of inpatient complications and outcomes after spinal fusion for CSM patients in the United States. We demonstrate the impacts of age, complications, and medical comorbidities on the outcome of surgery for patients with this common disorder. We provide complication rates stratified by age and medical comorbidities for elderly patients who present with CSM who need spinal fusion.
关于脊髓型颈椎病(CSM)行脊柱融合术后的院内并发症发生率、不良结局及死亡率的信息较少。本研究的目的是报告全国范围内的住院死亡率、并发症及结局情况。
我们利用全国住院患者样本,确定了1993年至2002年在美国接受脊柱融合术的58115例CSM患者的入院情况。进行多变量分析以分析患者和医院特征对死亡率、并发症、出院处置及住院时间等结局的影响。
共有58115例CSM患者接受了脊柱融合术,平均死亡率为0.6%,并发症发生率为13.4%,平均住院时间为4天。报告的最常见并发症为肺部并发症(3.6%)及术后出血或血肿(2.3%)。一种术后并发症导致平均住院时间增加4天,死亡率增加20倍,医院费用增加超过10000美元。多变量分析确定年龄、合并症及入院类型为死亡率、并发症发生率及不良结局的主要预测因素。年龄≥85岁或65至84岁的患者,与18至44岁年龄组的患者相比,死亡率分别增加44倍和14倍。84岁以上的患者不良结局增加40倍,发生医疗并发症的可能性增加5倍。有三种或更多合并症的患者发生医疗并发症(比值比[OR],1.98)、不良出院(OR,2.17)及院内死亡(OR,2.36)的风险增加。择期入院与低得多的死亡率(OR,0.28)、并发症发生率(OR,0.68)及不良结局发生率(OR,0.26)相关。后路融合术(16.4%)的并发症高于前路融合术(11.9%)。前路融合术与更高的吞咽困难发生率(3%)和声音嘶哑发生率(0.21%)相关。无脊髓病表现的颈椎病患者并发症发生率低得多(6.3%)。
我们提供了美国CSM患者脊柱融合术后住院并发症及结局的全国性估计。我们证明了年龄、并发症及医疗合并症对这种常见疾病患者手术结局的影响。我们为需要脊柱融合术的CSM老年患者提供了按年龄和医疗合并症分层的并发症发生率。