一些脊椎动物采用GLO。

Some vertebrates go with the GLO.

作者信息

Troadec Marie-Berengere, Kaplan Jerry

机构信息

Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA.

出版信息

Cell. 2008 Mar 21;132(6):921-2. doi: 10.1016/j.cell.2008.03.005.

DOI:10.1016/j.cell.2008.03.005

PMID:18358804

Abstract

Most vertebrates synthesize vitamin C (ascorbate) de novo from glucose, but humans and certain other mammals cannot. In this issue, Montel-Hagen et al. (2008) demonstrate that erythrocytes from these ascorbate auxotrophs switch the preference of their glucose transporter Glut1 from glucose to dehydroascorbate (DHA), the oxidized form of vitamin C. This substrate preference switch is mediated by the membrane protein stomatin and is an evolutionary adaptation to vitamin C deficiency.

摘要

大多数脊椎动物能从葡萄糖中从头合成维生素C（抗坏血酸），但人类和某些其他哺乳动物却不能。在本期杂志中，蒙泰尔 - 哈根等人（2008年）证明，这些抗坏血酸营养缺陷型动物的红细胞会将其葡萄糖转运蛋白Glut1的偏好从葡萄糖转变为脱氢抗坏血酸（DHA），即维生素C的氧化形式。这种底物偏好的转变由膜蛋白stomatin介导，是对维生素C缺乏的一种进化适应。