ALL-1基因的克隆，该基因座与伴有t(4;11)(q21;q23)、t(9;11)(p22;q23)和t(11;19)(q23;p13)染色体易位的白血病相关。
Cloning of ALL-1, the locus involved in leukemias with the t(4;11)(q21;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13) chromosome translocations.
作者信息
Cimino G, Moir D T, Canaani O, Williams K, Crist W M, Katzav S, Cannizzaro L, Lange B, Nowell P C, Croce C M
机构信息
Jefferson Cancer Institute, Jefferson Cancer Center, Philadelphia, Pennsylvania.
出版信息
Cancer Res. 1991 Dec 15;51(24):6712-4.
Chromosomal region 11q23 participates in a number of reciprocal translocations with specific regions of chromosomes 4, 9, 19, and others. These translocations are associated with acute lymphocytic leukemia and acute myelomonocytic, monocytic, and myelogenous leukemia. From a yeast artificial chromosome containing human DNA derived from 11q23 we cloned a DNA fragment which can be used as a probe to detect rearrangements in leukemic cells from the majority of patients with the t(4;11), t(9;11), and t(11;19) translocations. The breakpoints cluster in a small DNA region of less than 5.8 kilobases.
染色体区域11q23与染色体4、9、19及其他特定区域发生了许多相互易位。这些易位与急性淋巴细胞白血病以及急性粒单核细胞白血病、单核细胞白血病和粒细胞白血病相关。我们从一个含有源自11q23的人类DNA的酵母人工染色体中克隆了一个DNA片段，该片段可作为探针，用于检测大多数患有t(4;11)、t(9;11)和t(11;19)易位的白血病患者白血病细胞中的重排。断点聚集在一个小于5.8千碱基的小DNA区域内。
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