意大利阿尔茨海默病患者中 HLA-A2 等位基因的关联研究。

Association study of the HLA-A2 allele in Italian Alzheimer disease patients.

机构信息

Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Foundation IRCCS, Milan, Italy.

出版信息

Neurobiol Aging. 2009 Dec;30(12):2082-3. doi: 10.1016/j.neurobiolaging.2008.02.001. Epub 2008 Mar 21.

DOI:10.1016/j.neurobiolaging.2008.02.001

Abstract

Association of the A2 allele of the human leukocyte antigen (HLA) with Alzheimer disease (AD) is still controversial. The authors evaluated HLA-A2 association with AD in 173 Italian AD patients, considering also the possible interaction with APOE pattern, age of onset and gender. No evidence of any association was found.

摘要

人类白细胞抗原（HLA）A2 等位基因与阿尔茨海默病（AD）的关联仍存在争议。作者评估了 173 名意大利 AD 患者的 HLA-A2 与 AD 的关联，同时考虑了 APOE 模式、发病年龄和性别可能存在的相互作用。未发现任何关联的证据。