Asakawa Keiko, Rolfson Darryl, Senthilselvan Ambikaipakan, Feeny David, Johnson Jeffrey A
Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, Canada.
J Clin Epidemiol. 2008 Jul;61(7):733-9. doi: 10.1016/j.jclinepi.2007.09.007. Epub 2008 Mar 21.
To assess the cross-sectional construct validity of the Health Utilities Index Mark 3 (HUI3) in Alzheimer disease (AD), arthritis (AR), and cataracts (CA).
The 1996-97 Canadian National Population Health Survey for community and institution-dwelling respondents aged 40 years and above was used in the study. Adjusted means for overall and single-attribute HUI3 scores of five subgroups were compared: (1) AD only, (2) AR only, (3) CA only, (4) at least two of the three conditions, and (5) none of the three (reference group). Regression analyses were conducted for community and institutional data to obtain adjusted mean utility scores.
Of the 76 a priori hypotheses, 55 were confirmed. HUI3 was able to describe overall burdens of AD, AR, and CA as well as vision problems associated with CA, speech and cognition problems associated with AD, and ambulation and pain problems associated with AR. Adjusted mean differences in overall HUI3 scores between AD, AR, or CA only groups and reference group ranged from -0.04 to -0.42 (P<0.05); all differences were quantitatively important.
HUI3 is useful in assessing the health-related quality of life of AD, AR, and CA of those living in the community and institutions.
评估健康效用指数Mark 3（HUI3）在阿尔茨海默病（AD）、关节炎（AR）和白内障（CA）中的横断面结构效度。
本研究使用了1996 - 1997年加拿大全国人口健康调查，调查对象为40岁及以上居住在社区和机构中的受访者。比较了五个亚组的HUI3总分及单属性得分的调整均值：（1）仅患AD，（2）仅患AR，（3）仅患CA，（4）患有三种疾病中的至少两种，（5）三种疾病均未患（参照组）。对社区和机构数据进行回归分析以获得调整后的平均效用得分。
在76个先验假设中，55个得到证实。HUI3能够描述AD、AR和CA的总体负担，以及与CA相关的视力问题、与AD相关的言语和认知问题，以及与AR相关的行走和疼痛问题。仅患AD、AR或CA组与参照组之间HUI3总分的调整均值差异范围为 - 0.04至 - 0.42（P<0.05）；所有差异在数量上都具有重要意义。
HUI3有助于评估社区和机构中AD、AR和CA患者与健康相关的生活质量。
