Rohl Jacqueline, Kjerulff Kristen, Langenberg Patricia, Steege John
Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH, USA.
Am J Obstet Gynecol. 2008 Jul;199(1):22.e1-5. doi: 10.1016/j.ajog.2008.01.043. Epub 2008 Mar 24.
This study was performed to examine whether bilateral oophorectomy is related to depressive symptoms.
A secondary analysis of data collected from a cohort study of 1047 premenopausal women undergoing hysterectomy with or without concomitant oophorectomy for benign indications was performed. Data on depressive symptoms, based on the Profile of Mood States survey, were collected presurgically and 12 months postoperatively.
The effect of bilateral oophorectomy on postoperative depressive symptoms varied, depending on the presence of baseline depressive symptoms. Bilateral oophorectomy was associated with a decrease in risk of depressive symptoms in women without baseline depressive symptoms (risk ratio [RR] 0.36 [95% confidence interval (CI), 0.17, 0.78]) and did not change significantly in those with baseline depressive symptoms (RR 1.21 [95% CI, 0.73, 2.00]).
Bilateral oophorectomy, in comparison with unilateral or no oophorectomy, is associated with less risk of postoperative depressive symptoms in women without baseline depressive symptoms undergoing hysterectomy.
本研究旨在探讨双侧卵巢切除术是否与抑郁症状有关。
对一项队列研究收集的数据进行二次分析，该队列研究纳入了1047名因良性指征接受子宫切除术并伴有或不伴有卵巢切除术的绝经前女性。基于情绪状态量表调查收集术前及术后12个月的抑郁症状数据。
双侧卵巢切除术对术后抑郁症状的影响各不相同，这取决于基线抑郁症状的存在情况。对于无基线抑郁症状的女性，双侧卵巢切除术与抑郁症状风险降低相关（风险比[RR] 0.36 [95%置信区间(CI)，0.17，0.78]），而对于有基线抑郁症状的女性，风险无显著变化（RR 1.21 [95% CI，0.73，2.00]）。
与单侧卵巢切除术或未行卵巢切除术相比，对于无基线抑郁症状且接受子宫切除术的女性，双侧卵巢切除术与术后抑郁症状风险较低相关。
