Chen Zhuang-gui, Li Ming, Chen Hong, Chen Yan-feng, Chen Fen-hua, Ji Jing-zhi
Department of Pediatrics, Third Hospital Affiliated to Sun Yat-sen University, Guangzhou 510630, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2008 Mar;28(3):470-2.
To evaluate the efficacy of 3 commonly used protocols for management of acute exacerbation of asthma in children.
Totally 113 asthmatic children were randomized into 3 groups. In group A (53 cases), the children were treated with inhalation of nebulized budesonide suspension plus salbutamol and ipratropium bromide twice daily for 5 days; in group B (41 cases), budesonide plus salbutamol and ipratropium aerosol was administered, and in group C (29 cases), dexathmisone plus aminophylline injection was given once daily for 5 days. All the children received basic treatment with fluid infusion, antibiotics or/and anti-virus medications.
The children in both groups A and C showed effectively controlled asthma attack, with significant differences in the therapeutic effects (P>0.05). In contrast, only a few children showed improvement in group B, suggesting the ineffectiveness of the treatment.
Nebulized medicine is one of the best means for management of acute asthma exacerbation in children, and inhalation of budesonide suspension plus salbutamol and ipratropium bromide can effectively relieve the asthmatic symptoms in these children with good compliance and convenient administration.
评估3种常用方案治疗儿童哮喘急性加重期的疗效。
将113例哮喘患儿随机分为3组。A组（53例）患儿采用雾化吸入布地奈德混悬液加沙丁胺醇及异丙托溴铵，每日2次，共5天；B组（41例）给予布地奈德加沙丁胺醇及异丙托溴铵气雾剂；C组（29例）给予地塞米松加氨茶碱注射液，每日1次，共5天。所有患儿均接受补液、抗生素或/和抗病毒药物的基础治疗。
A组和C组患儿哮喘发作均得到有效控制，治疗效果差异有统计学意义（P>0.05）。相比之下，B组仅有少数患儿病情改善，提示该治疗方案无效。
雾化吸入是治疗儿童急性哮喘加重期的最佳方法之一，吸入布地奈德混悬液加沙丁胺醇及异丙托溴铵可有效缓解患儿哮喘症状，依从性好，给药方便。
