Cheung L P, Ma R C W, Lam P M, Lok I H, Haines C J, So W Y, Tong P C Y, Cockram C S, Chow C C, Goggins W B
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China.
Hum Reprod. 2008 Jun;23(6):1431-8. doi: 10.1093/humrep/den090. Epub 2008 Mar 21.
Women with polycystic ovary syndrome (PCOS) frequently exhibit central obesity, glucose intolerance, atherogenic dyslipidaemia and hypertension which are characteristic features of the metabolic syndrome (MetS).
A total of 295 premenopausal Chinese women with PCOS diagnosed by the Rotterdam criteria (mean age: 30.2 +/- 6.4 years) and 98 control subjects without PCOS were evaluated for prevalence of MetS and cardiovascular risk factors, including dyslipidaemia and dysglycaemia.
Using the 2005 modified Adult Treatment Panel III criteria, MetS (presence of three or more risk factors) was found in 24.9% of PCOS women compared to 3.1% of controls. The prevalence of MetS in PCOS women increased from 16.7% at under 30 years of age to 53.3% at over 40 years. MetS was also more prevalent in overweight and obese (41.3%) than normal-weight PCOS women (0.9%). However, multivariate regression analysis showed that women with PCOS had a 5-fold increase in risk of MetS (odds ratio 4.90; 95% confidence interval: 1.35-17.84) compared with women without PCOS even after controlling for age and BMI, suggesting PCOS alone is an independent risk factor for MetS.
There is high prevalence of MetS in Hong Kong Chinese women with PCOS despite their relatively young age. Recognition of these cardiometabolic risk factors requires a high level of awareness in conjunction with early and regular screening.
多囊卵巢综合征（PCOS）女性常表现出中心性肥胖、糖耐量异常、致动脉粥样硬化性血脂异常和高血压，这些都是代谢综合征（MetS）的特征性表现。
对295例根据鹿特丹标准诊断的绝经前中国PCOS女性（平均年龄：30.2±6.4岁）和98例无PCOS的对照者进行评估，以确定MetS及心血管危险因素的患病率，包括血脂异常和血糖异常。
采用2005年修订的成人治疗小组III标准，24.9%的PCOS女性存在MetS（有三个或更多危险因素），而对照组为3.1%。PCOS女性中MetS的患病率从30岁以下的16.7%增至40岁以上的53.3%。超重和肥胖的PCOS女性（41.3%）中MetS也比正常体重的PCOS女性（0.9%）更常见。然而，多因素回归分析显示，即使在控制年龄和体重指数后，PCOS女性发生MetS的风险仍比无PCOS女性高5倍（比值比4.90；95%置信区间：1.35 - 17.84），提示PCOS本身就是MetS的独立危险因素。
香港华裔PCOS女性中MetS患病率很高，尽管她们相对年轻。认识这些心脏代谢危险因素需要高度的意识以及早期和定期筛查。
