Al Duraihimh Huda, Ghamdi Ghormullah, Moussa Dujana, Shaheen Faissal, Mohsen Nabil, Sharma Usha, Stephan Antoine, Alfie Adnan, Alamin Mohamed, Haberal Mehmet, Saeed Bassam, Kechrid Mohamed, Al-Sayyari Abdulla
Department of Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
Transplantation. 2008 Mar 27;85(6):840-3. doi: 10.1097/TP.0b013e318166ac45.
To study the pregnancy and offspring outcomes in postrenal transplant recipients.
This is a retrospective case-note review study investigating the outcome of 234 pregnancies in 140 renal transplant recipients from five different Middle Eastern countries.
Of the overall pregnancies 74.4% were successful albeit with high prevalences of preterm and Caesarean deliveries (40.8% and 53%, respectively). The mean serum creatinine did not rise significantly during pregnancy in the group as a whole but did so in patients who had serum creatinine of or above 150 micromol/L at the beginning of their pregnancies. The mean birth weight was (2,458 g) with 41.3% of the newborns being of low birth weight (<2,500 g). The prevalences of stillbirths were 7.3% and of spontaneous abortion was 19.3%. Preeclampsia and gestational diabetes were observed in 26.1% and 2% of pregnancies, respectively.
In the presence of good allograft function, the majority of pregnancies in renal transplant recipients have a good outcome but with increased incidence of preeclampsia, reduced gestational age, and low birth weights. Patients with baseline serum creatinine of above 150 micromol/L have an increased risk of allograft dysfunction resulting from the pregnancy.
研究肾移植受者的妊娠及子代结局。
这是一项回顾性病例笔记审查研究，调查了来自五个不同中东国家的140名肾移植受者的234次妊娠结局。
在所有妊娠中，74.4%成功，但早产和剖宫产的发生率较高（分别为40.8%和53%）。总体而言，妊娠期间该组患者的平均血清肌酐没有显著升高，但妊娠开始时血清肌酐达到或高于150微摩尔/升的患者血清肌酐升高。平均出生体重为（2458克），41.3%的新生儿为低出生体重（<2500克）。死产率为7.3%，自然流产率为19.3%。子痫前期和妊娠期糖尿病的发生率分别为26.1%和2%。
在移植肾功能良好的情况下，肾移植受者的大多数妊娠结局良好，但子痫前期发生率增加、孕周缩短和出生体重低。基线血清肌酐高于150微摩尔/升的患者因妊娠导致移植肾功能障碍的风险增加。
