Ther Clin Risk Manag. 2005 Jun;1(2):77-82. doi: 10.2147/tcrm.1.2.77.62911.
This paper overviews the controversies surrounding the abuse of prescription analgesic OxyContin((R)) (oxycodone hydrochloride; Purdue Pharma, Stamford, CT, USA). It discusses solutions to this medication-related issue, which has been touted as reaching epidemic proportions. Relevant literature from 1990 to 2004 was identified through a MEDLINE search, and a thorough internet-based search was conducted to obtain the latest updates and government reports. OxyContin became popular as a street drug through its ability to induce a quick heroin-like euphoria. The media hype surrounding OxyContin abuse and the "black box" warning on its label may have added to the abuse and diversion. The US Food and Drug Administration took steps by writing letters to Purdue Pharma, the manufacturers of OxyContin. Purdue Pharma developed a database to identify OxyContin abusers throughout the nation and also launched campaigns to educate patients through the internet. Further suggestions to managing the abuse of OxyContin include: community pharmacists' assessment of behavioral risk factors that could lead to patient medication abuse; medication abuse risk management courses for physicians; development of a national database linking all pharmacies specifically designed to identify abusers; and tamper-resistant prescription pads for controlled substances, which seems the most plausible and immediate solution to this problem.
本文概述了围绕处方止痛药奥施康定（羟考酮盐酸盐；普渡制药，斯坦福德，CT，美国）滥用的争议。它讨论了解决这一与药物相关的问题的方法，该问题已被吹捧为达到流行的程度。通过 MEDLINE 搜索确定了 1990 年至 2004 年的相关文献，并进行了全面的基于互联网的搜索，以获取最新的更新和政府报告。奥施康定因其能够引起快速类似海洛因的快感而成为一种流行的街头毒品。围绕奥施康定滥用和标签上的“黑框警告”的媒体炒作可能加剧了滥用和转移。美国食品和药物管理局通过给奥施康定的制造商普渡制药写信采取了措施。普渡制药开发了一个数据库，以识别全国范围内的奥施康定滥用者，并通过互联网开展了教育患者的活动。管理奥施康定滥用的进一步建议包括：社区药剂师评估可能导致患者药物滥用的行为风险因素；为医生开设药物滥用风险管理课程；开发一个全国性的数据库，将所有药店联系起来，专门用于识别滥用者；以及用于管制物质的防篡改处方垫，这似乎是解决这个问题的最合理和最直接的方法。
