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阿片类药物复方制剂奥施康定引入后网络上报告的药物使用模式变化:来自药物滥用、转移和成瘾相关监测(RADARS)系统网络监测项目的研究结果

Changes in drug use patterns reported on the web after the introduction of ADF OxyContin: findings from the Researched Abuse, Diversion, and Addiction-Related Surveillance (RADARS) System Web Monitoring Program.

作者信息

Vosburg Suzanne K, Haynes Colleen, Besharat Andrea, Green Jody L

机构信息

Rocky Mountain Poison and Drug Center (RMPDC), A Division of Denver Health, 777 Bannock Street M/C 0180, Denver, Colorado, 80204, USA.

出版信息

Pharmacoepidemiol Drug Saf. 2017 Sep;26(9):1044-1052. doi: 10.1002/pds.4248. Epub 2017 Jun 27.

Abstract

UNLABELLED

This qualitative study summarizes information that individuals shared online about use of OxyContin following the August 2010 introduction of the abuse deterrent formulation (ADF).

PURPOSE

The primary objective was to study online posts that endorsed continued use of OxyContin or a switch from OxyContin to another formulation of oxycodone or another substance altogether following the introduction of the ADF. A secondary objective was to determine whether posts revealed that the ADF led to cessation of OxyContin use.

METHODS

Data were collected with the Researched Abuse, Diversion, and Addiction-Related Surveillance System Web Monitoring Program, an online surveillance system that collects and organizes posts about prescription drugs from social media websites, blogs, and forums from 3Q2009 to 4Q2014 using a commercially available web platform.

RESULTS

Posts were categorized by whether they conveyed a switch to drugs other than reformulated OxyContin or a continuation of reformulated OxyContin abuse. "Switch posts" primarily discussed switching to immediate-release opioids. "Continue abusing" posts identified tampering strategies for alternate routes of administration, oral use, and continued use although post authors were generally unhappy with the experience. No reference to OxyContin cessation as a function of the introduction of the ADF was found; however, discontinued use was discussed.

CONCLUSIONS

Web Monitoring data are useful for capturing cross sections of Internet conversation reflecting reactions to new drug formulations. These data support the notion that users will gravitate to non-ADFs generally, and to immediate-release non-ADF opioid formulations, specifically, as long as these options remain on the market.

摘要

未标注

本定性研究总结了2010年8月引入滥用威慑剂型(ADF)后,个人在网上分享的关于使用奥施康定的信息。

目的

主要目的是研究在引入ADF后,支持继续使用奥施康定或从奥施康定转向另一种羟考酮剂型或完全转向另一种物质的网上帖子。次要目的是确定这些帖子是否表明ADF导致奥施康定使用停止。

方法

数据通过研究滥用、转移和成瘾相关监测系统网络监测项目收集,该在线监测系统使用商业网络平台,从2009年第三季度到2014年第四季度收集和整理来自社交媒体网站、博客和论坛的关于处方药的帖子。

结果

帖子根据其是否传达转向重新配方的奥施康定以外的药物或继续滥用重新配方的奥施康定进行分类。“转向帖子”主要讨论转向即释阿片类药物。“继续滥用”帖子确定了替代给药途径、口服使用和继续使用的篡改策略,尽管帖子作者通常对这种体验不满意。未发现有提及因引入ADF而停止使用奥施康定的情况;然而,讨论了停止使用的情况。

结论

网络监测数据有助于捕捉反映对新药物剂型反应的互联网对话的横断面。这些数据支持这样一种观点,即只要这些选择仍在市场上,用户通常会倾向于非ADF药物,特别是倾向于即释非ADF阿片类药物剂型。

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