Clinical Neurodermatology, Department of Dermatology, University Hospital Münster Germany.
Ther Clin Risk Manag. 2006 Jun;2(2):213-8. doi: 10.2147/tcrm.2006.2.2.213.
The introduction of topical calcineurin inhibitors resulted in a significant improvement in the treatment of atopic dermatitis. In addition, rapid amelioration of pruritus could be observed. In case reports, other pruritic dermatoses such as chronic irritative hand dermatitis, rosacea, graft-versus-host-disease, and lichen sclerosus were also treated successfully with pimecrolimus and tacrolimus. Twenty patients were treated with tacrolimus and pimecrolimus in a surveillance study to evaluate efficacy in pruritus and prurigo. Eighteen of 20 patients responded to therapy. Best results were obtained in localized and generalized pruritus while in prurigo nodularis only a subgroup of patients showed an improvement of pruritus. Further controlled studies are necessary to confirm these results.
局部和泛发性瘙痒的患者治疗效果最佳，而在结节性瘙痒症患者中，仅有一部分患者瘙痒症状得到改善。需要进一步的对照研究来证实这些结果。
