Evtushenko E S, Bazanova E A, Liampert I M, Borodiiuk N A, Asoskova T K, Sitnikova V P, Goriaĭnova A N
Biull Eksp Biol Med. 1991 Sep;112(9):267-9.
By the acute glomerulonephritis (GN) of streptococcal etiology, autoantibodies (AA) reacting with the basal layer of skin epithelium (BLSE) are discovered. The presence of this AA's correlate with the high level of antibodies to the streptococcal group A polysaccharide (A-PS). In the control sera such AA's and the high level antibodies to A-PS are discovered very rarely. By the GN of non-streptococcal etiology, AA's to the BLSE apparently of other specificity are obtained in some cases, in spite of the absence of antibodies to A-PS. AA's reacting with the differentiated layers of skin epithelium are discovered in the high percent of cases by GN. The presence of these AA's do not correlate with the levels of antibodies to A-PS. The reduction of the number of T-lymphocyte suppressors is established in the blood by the presence of AA's to the BLSE by GN. This question is a subject of later investigations by the different autoimmune processes. Such data can apparently corroborate the previously expressed hypothesis, that AA's to BLSE, which as a rule react with endocrine thymus epithelium, are the cause of the beginning of immunoregulatory disorders, characteristic of autoimmune processes.
在由链球菌病因引起的急性肾小球肾炎（GN）中，发现了与皮肤上皮基底膜（BLSE）发生反应的自身抗体（AA）。这些自身抗体的存在与抗A群链球菌多糖（A-PS）抗体的高水平相关。在对照血清中，这种自身抗体和抗A-PS的高水平抗体很少被发现。在非链球菌病因引起的GN中，尽管不存在抗A-PS抗体，但在某些情况下仍能获得明显具有其他特异性的针对BLSE的自身抗体。在高比例的GN病例中发现了与皮肤上皮分化层发生反应的自身抗体。这些自身抗体的存在与抗A-PS抗体水平无关。通过GN患者血清中存在针对BLSE的自身抗体，证实其血液中T淋巴细胞抑制因子数量减少。这个问题是后续不同自身免疫过程研究的主题。这些数据显然可以证实先前提出的假设，即通常与内分泌胸腺上皮发生反应的针对BLSE的自身抗体是免疫调节紊乱开始的原因，这是自身免疫过程的特征。
