人初乳含有一种抑制白细胞介素-2产生的活性物质。
Human colostrum contains an activity that inhibits the production of IL-2.
作者信息
Hooton J W, Pabst H F, Spady D W, Paetkau V
机构信息
Department of Biochemistry, Walter MacKenzie Center, University of Alberta, Edmonton, Canada.
出版信息
Clin Exp Immunol. 1991 Dec;86(3):520-4. doi: 10.1111/j.1365-2249.1991.tb02963.x.
The effect of human colostrum on T cell immune function was investigated. Colostrum inhibited the proliferation of human T cells activated by allogeneic, concanavalin A (Con A) or phytohaemagglutinin (PHA) stimulation. Colostrum also inhibited the production of IL-2 by Con A-activated human peripheral blood T cells and by Con A-activated Jurkat cells, a human T lymphoma line. Similarly, human colostrum inhibited the production of IL-2 by EL4 cells, a murine thymoma line, when stimulated with phorbol myristate acetate. The inhibitory activity was not cytotoxic and could not be neutralized by antibody to transforming human growth factor beta.
研究了人初乳对T细胞免疫功能的影响。初乳抑制了由同种异体、刀豆蛋白A（Con A）或植物血凝素（PHA）刺激激活的人T细胞的增殖。初乳还抑制了Con A激活的人外周血T细胞和Con A激活的人T淋巴瘤细胞系Jurkat细胞产生白细胞介素-2（IL-2）。同样，当用佛波酯肉豆蔻酸酯刺激时，人初乳抑制了小鼠胸腺瘤细胞系EL4细胞产生IL-2。这种抑制活性没有细胞毒性，并且不能被抗转化生长因子β的抗体中和。
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