人初乳对白细胞介素-2产生及自然杀伤细胞活性的影响。
Effect of human colostrum on interleukin-2 production and natural killer cell activity.
作者信息
Sirota L, Straussberg R, Notti I, Bessler H
机构信息
Neonatology Unit, Golda Medical Center, Hasharon Hospital, Petah-Tiqva, Tel Aviv University, Israel.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1995 Sep;73(2):F99-102. doi: 10.1136/fn.73.2.f99.
The effect of human colostrum on the production of interleukin-2 (IL-2) and on natural killer (NK) cell activity by peripheral blood mononuclear cells (PBMC) was investigated in 50 healthy women. At concentrations as low as 0.5%, human colostrum stimulated IL-2 production; at a higher concentration (10%), IL-2 secretion was inhibited. A time and dose dependent inhibitory effect of colostrum on NK cytotoxicity was also observed. This inhibition could be reversed by the addition of human recombinant IL-2 (hrIL-2). The stimulation of IL-2 production induced by human colostrum might compensate for its inhibitory effect on NK cell activity. These findings suggest an additional mechanism by which breast feeding may affect the neonatal immune system.
在50名健康女性中研究了人初乳对外周血单个核细胞（PBMC）产生白细胞介素-2（IL-2）及自然杀伤（NK）细胞活性的影响。人初乳在低至0.5%的浓度时可刺激IL-2的产生；在较高浓度（10%）时，IL-2分泌受到抑制。还观察到初乳对NK细胞毒性具有时间和剂量依赖性的抑制作用。加入人重组IL-2（hrIL-2）可逆转这种抑制作用。人初乳诱导的IL-2产生的刺激作用可能补偿其对NK细胞活性的抑制作用。这些发现提示了母乳喂养可能影响新生儿免疫系统的另一种机制。
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