Tazume S, Umehara K, Matsuzawa H, Yoshida T, Hashimoto K, Sasaki S
Department of Microbiology, School of Medicine, Tokai University, Kanagawa, Japan.
Jikken Dobutsu. 1991 Oct;40(4):523-8. doi: 10.1538/expanim1978.40.4_523.
The effects of food restriction on immune function was investigated in germfree (GF) and specific pathogen-free (SPF) mice. They were maintained from five weeks of age under either full-fed or food-restricted conditions to 4.5 grams per day (equivalent to approximately 80% of full-fed intake) of a commercial diet. Longest survival rate was attained in food-restricted SPF mice followed by food-restricted GF, full-fed GF, and full-fed SPF animals. Food-restricted GF mice showed shorter survival rate than their SPF counterparts. This result suggests that food restriction may be just as effective as GF status for extending life span. Immune function declined significantly with age in full-fed groups of GF and SPF mice. In both food-restricted GF and SPF mice, mitogenic response to concanavalin A or lipopolysaccharide and antibody response to sheep red blood cells were lower early in life and became higher later in life as compared with full-fed mice. Hence, the maintenance of effective immunological function until old age may be the reason for food-restricted groups to live slightly longer than full-fed groups.
在无菌（GF）和无特定病原体（SPF）小鼠中研究了食物限制对免疫功能的影响。从五周龄开始，将它们分别维持在全喂养或食物限制条件下，给予商业饮食，食物限制组每天4.5克（约相当于全喂养摄入量的80%）。食物限制的SPF小鼠的最长存活率最高，其次是食物限制的GF小鼠、全喂养的GF小鼠和全喂养的SPF小鼠。食物限制的GF小鼠的存活率低于其SPF对应组。这一结果表明，食物限制在延长寿命方面可能与GF状态同样有效。在全喂养的GF和SPF小鼠组中，免疫功能随年龄显著下降。与全喂养小鼠相比，在食物限制的GF和SPF小鼠中，对刀豆球蛋白A或脂多糖的促有丝分裂反应以及对绵羊红细胞的抗体反应在生命早期较低，而在生命后期较高。因此，食物限制组比全喂养组寿命稍长的原因可能是其直到老年都能维持有效的免疫功能。
