对氧磷酶-1和对氧磷酶-2基因多态性与急性心肌梗死风险的关联

[Association between paraoxonase-1 and paraoxonase-2 polymorphisms and the risk of acute myocardial infarction].

作者信息

Guxens Mònica, Tomás Marta, Elosua Roberto, Aldasoro Elena, Segura Antonio, Fiol Miquel, Sala Joan, Vila Joan, Fullana Maria, Sentí Mariano, Vega Gema, de la Rica Mónica, Marrugat Jaume

机构信息

Unitat de Lípids i Epidemiologia Cardiovascular, Institut Municipal d'Investigació Mèdica, Barcelona, España.

出版信息

Rev Esp Cardiol. 2008 Mar;61(3):269-75.

PMID:18361900

Abstract

INTRODUCTION AND OBJECTIVES

Two particular polymorphisms, namely PON1-192 and PON2-311, in the genes encoding the antioxidant enzymes paraoxonase-1 (PON1) and paraoxonase-2 (PON2) have been associated with an increased risk of acute myocardial infarction (AMI). However, previous findings have been contradictory. The aim of this study was to investigate the association between the PON1-192 and PON2-311 polymorphisms and their interaction on AMI risk.

METHODS

This case-control study involved 746 consecutive AMI patients and 1796 control subjects without cardiovascular disease, who were randomly selected from the same population from which the patients came. All participants were recruited between 1999 and 2000 from four Spanish autonomous regions. All were assessed for the presence of PON1-192 and PON2-311 and for classical cardiovascular risk factors. Multivariate analysis was carried out using logistic regression modeling.

RESULTS

The odds ratios (OR) of AMI for patients with the PON1-192 QQ and PON2-311 SS genotypes (who comprised 50% and 66% of the population, respectively) were 1.26 (95% confidence interval [CI], 1.02-1.55) and 1.25 (95% CI, 1.04-1.50), respectively, compared with R and C allele carriers. Moreover, in patients with both QQ and SS genotypes, the adjusted OR of AMI increased to 1.41 (95% CI, 1.13-1.76).

CONCLUSIONS

Our results indicate that the PON1-192 and PON2-311 polymorphisms were independent risk factors of AMI in our population.

摘要

引言与目的

编码抗氧化酶对氧磷酶-1（PON1）和对氧磷酶-2（PON2）的基因中存在两种特定的多态性，即PON1-192和PON2-311，它们与急性心肌梗死（AMI）风险增加相关。然而，先前的研究结果相互矛盾。本研究的目的是调查PON1-192和PON2-311多态性与它们对AMI风险的相互作用之间的关联。

方法

本病例对照研究纳入了746例连续的AMI患者和1796例无心血管疾病的对照受试者，这些对照受试者是从与患者相同的人群中随机选取的。所有参与者于1999年至2000年期间从四个西班牙自治区招募。对所有参与者评估PON1-192和PON2-311的存在情况以及经典心血管危险因素。使用逻辑回归模型进行多变量分析。

结果

与R和C等位基因携带者相比，PON1-192 QQ基因型（分别占人群的50%）和PON2-311 SS基因型（分别占人群的66%）患者发生AMI的比值比（OR）分别为1.26（95%置信区间[CI]，1.02 - 1.55）和1.25（95% CI，1.04 - 1.50）。此外，在同时具有QQ和SS基因型的患者中，AMI的校正OR增加至1.41（95% CI，1.13 - 1.76）。