Loveridge J A, Rosenberg W M, Kirkwood T B, Bell J I
Institute of Molecular Medicine, John Radcliffe Hospital, Headington, U.K.
Immunology. 1991 Oct;74(2):246-50.
Recent studies in mice have highlighted the importance of polymorphic genetic loci such as the major histocompatibility complex (MHC) or minor lymphocyte-stimulating antigen (Mls) in determining the nature of the peripheral T-cell receptor (TcR) population. As our knowledge of the equivalent process in humans is incomplete, we have utilized a modification of the polymerase chain reaction (PCR) to determine the overall genetic contribution to the normal human TcR variable V beta gene repertoire. These data demonstrate that the normal human T-cell population contains members of all the major TcR V beta families and that there is considerable variation in the relative amounts of specific TcR V beta transcripts between individuals. We have established that the normal peripheral TcR V beta repertoire is more concordant in identical twins than in unrelated individuals. The relative importance of genetic factors in determining the peripheral TcR repertoire is emphasized by these results and suggests that, in humans, the genetic control of immune responsiveness is mediated in part by the peripheral TcR repertoire.
近期对小鼠的研究突出了多态性基因座（如主要组织相容性复合体（MHC）或次要淋巴细胞刺激抗原（Mls））在决定外周T细胞受体（TcR）群体性质方面的重要性。由于我们对人类等效过程的了解并不完整，我们采用了聚合酶链反应（PCR）的一种改良方法来确定对正常人类TcR可变Vβ基因库的总体遗传贡献。这些数据表明，正常人类T细胞群体包含所有主要TcR Vβ家族的成员，并且个体之间特定TcR Vβ转录本的相对量存在相当大的差异。我们已经确定，同卵双胞胎的正常外周TcR Vβ基因库比无关个体的更为一致。这些结果强调了遗传因素在决定外周TcR基因库中的相对重要性，并表明在人类中，免疫反应性的遗传控制部分是由外周TcR基因库介导的。
