HLA-DQβ基因与胰岛素依赖型糖尿病的易感性和抗性有关。
HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus.
作者信息
Todd J A, Bell J I, McDevitt H O
机构信息
Department of Medical Microbiology, Stanford University School of Medicine, California 94305.
出版信息
Nature. 1987;329(6140):599-604. doi: 10.1038/329599a0.
Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determine both disease susceptibility and resistance, and that the structure of the DQ molecule, in particular residue 57 of the beta-chain, specifies the autoimmune response against the insulin-producing islet cells.
超过一半的胰岛素依赖型糖尿病遗传易感性定位于6号染色体上包含高度多态性HLA II类基因的区域，这些基因决定免疫反应性。对糖尿病患者DNA序列的分析表明，HLA-DQβ等位基因决定疾病易感性和抗性，并且DQ分子的结构，特别是β链的第57位残基，决定了针对产生胰岛素的胰岛细胞的自身免疫反应。
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