Alway Stephen E, Siu Parco M
Laboratory of Muscle Biology and Sarcopenia, Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV 26506-9227, USA.
Exerc Sport Sci Rev. 2008 Apr;36(2):51-7. doi: 10.1097/JES.0b013e318168e9dc.
Apoptosis results in DNA fragmentation and, subsequently, destruction of cells containing a single nucleus. Our hypothesis is that multinucleated cells such as muscle fibers can experience apoptotic-induced loss of single nuclei (nuclear apoptosis) without destruction of the entire fiber. The loss of nuclei likely contributes to atrophy and sarcopenia. Furthermore, increased chronic activity attenuates apoptotic signaling, which may reduce sarcopenia.
细胞凋亡会导致DNA片段化,随后,含有单个细胞核的细胞会被破坏。我们的假设是,诸如肌纤维等多核细胞可以经历由凋亡诱导的单个细胞核的丢失(核凋亡),而不会破坏整个纤维。细胞核的丢失可能导致萎缩和肌肉减少症。此外,增加慢性活动会减弱凋亡信号传导,这可能会减少肌肉减少症。