Chichkovskaia G V, Parkhomets P K, Kuchmerovskaia T M, Khalmuradov A A, Donchenko G V, Rozhanskaia O P
Vopr Med Khim. 1991 Jul-Aug;37(4):63-5.
Content of nicotinamide nucleotides, reception of NAD by synaptic membranes and the system of 14C-serotonin uptake and liberation in rat brain nerve endings were studied under various conditions of vitamin PP consumption. In PP hypovitaminosis binding of 14C-NAD was decreased in synaptic membranes as a result of alterations in capacity of receptor sites, which occurred simultaneously with low level of nicotinamide coenzymes in rat brain. These alterations led to deterioration of NAD modulating function in liberation of 14C-serotonin from synaptosomes. The data obtained suggest that functional activity of NAD-receptor system in synaptic membranes of rat brain depends on the rate of vitamin PP consumption. These results might be considered in clinical research when vitamin PP is used for treatment of various diseases.
在不同维生素PP摄入条件下，研究了大鼠脑神经末梢中烟酰胺核苷酸的含量、突触膜对NAD的摄取以及14C - 5 - 羟色胺摄取和释放系统。在PP维生素缺乏症中，由于受体位点能力的改变，突触膜中14C - NAD的结合减少，这与大鼠脑中烟酰胺辅酶水平低同时发生。这些改变导致NAD调节突触体中14C - 5 - 羟色胺释放的功能恶化。所得数据表明，大鼠脑突触膜中NAD - 受体系统的功能活性取决于维生素PP的摄入速率。当使用维生素PP治疗各种疾病时，这些结果可在临床研究中予以考虑。
